ID   PTTG3_PANTR             Reviewed;         202 AA.
AC   Q2QD15;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative pituitary tumor-transforming gene 3 protein;
DE   AltName: Full=Securin-3;
DE   AltName: Full=rcPTTG1;
GN   Name=PTTG3;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16201836; DOI=10.1371/journal.pbio.0030357;
RA   Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.;
RT   "Emergence of young human genes after a burst of retroposition in
RT   primates.";
RL   PLoS Biol. 3:E357-E357(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal destruction box (D-box) acts as a recognition
CC       signal for degradation via the ubiquitin-proteasome pathway.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the securin family. {ECO:0000305}.
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DR   EMBL; DQ120701; ABC40664.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2QD15; -.
DR   Ensembl; ENSPTRT00000078226; ENSPTRP00000088706; ENSPTRG00000052460.
DR   GeneTree; ENSGT00390000009693; -.
DR   InParanoid; Q2QD15; -.
DR   OMA; EPGIHMA; -.
DR   Proteomes; UP000002277; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0045143; P:homologous chromosome segregation; IBA:GO_Central.
DR   GO; GO:2000816; P:negative regulation of mitotic sister chromatid separation; IBA:GO_Central.
DR   InterPro; IPR006940; Securin_separation_inhibitor.
DR   PANTHER; PTHR10418; PTHR10418; 1.
DR   Pfam; PF04856; Securin; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Proto-oncogene; Reference proteome; SH3-binding.
FT   CHAIN           1..202
FT                   /note="Putative pituitary tumor-transforming gene 3
FT                   protein"
FT                   /id="PRO_0000333861"
FT   MOTIF           61..64
FT                   /note="D-box"
FT                   /evidence="ECO:0000250"
FT   MOTIF           163..173
FT                   /note="SH3-binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   202 AA;  21967 MW;  6CB7E2D0F4CB56D3 CRC64;
     MATLIYVDKE NEEPGTLVAT TDGLKLGSGP SIKALDGRSQ VSISCFGKTF DAPTSLPKAT
     RKALGTVNRA TEKSVKTNGP LKQKQPSFSA KKMTEKTVKA KNSVPASDDA YPEIEKLFPF
     NPLGFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPLKMP SPPWKSNLLQ
     SPLSILLTLD VELPPVCSDI DI