ID   PTTG_PONAB              Reviewed;         180 AA.
AC   Q5NVI6; Q5RDG9; Q5RE91;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Pituitary tumor-transforming gene 1 protein-interacting protein;
DE   AltName: Full=Pituitary tumor-transforming gene protein-binding factor;
DE            Short=PBF;
DE            Short=PTTG-binding factor;
DE   Flags: Precursor;
GN   Name=PTTG1IP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May facilitate PTTG1 nuclear translocation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PTTG1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=May be cytoplasmic and nuclear. {ECO:0000250}.
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DR   EMBL; CR857642; CAH89916.1; -; mRNA.
DR   EMBL; CR857941; CAH90188.1; -; mRNA.
DR   EMBL; CR926045; CAI29677.1; -; mRNA.
DR   RefSeq; NP_001127103.1; NM_001133631.1.
DR   RefSeq; NP_001128770.1; NM_001135298.1.
DR   AlphaFoldDB; Q5NVI6; -.
DR   SMR; Q5NVI6; -.
DR   Ensembl; ENSPPYT00000035073; ENSPPYP00000033601; ENSPPYG00000036754.
DR   GeneID; 100174140; -.
DR   GeneID; 100189668; -.
DR   KEGG; pon:100174140; -.
DR   CTD; 754; -.
DR   eggNOG; ENOG502RYM1; Eukaryota.
DR   GeneTree; ENSGT00390000004977; -.
DR   InParanoid; Q5NVI6; -.
DR   OrthoDB; 1458076at2759; -.
DR   Proteomes; UP000001595; Chromosome 21.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR   GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
DR   GO; GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR042492; PTTG1IP.
DR   PANTHER; PTHR15191:SF2; PTHR15191:SF2; 1.
DR   SMART; SM00423; PSI; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Cytoplasm; Glycoprotein; Membrane; Nucleus;
KW   Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..180
FT                   /note="Pituitary tumor-transforming gene 1 protein-
FT                   interacting protein"
FT                   /id="PRO_0000022186"
FT   TOPO_DOM        33..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          39..92
FT                   /note="PSI"
FT   REGION          131..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          130..166
FT                   /evidence="ECO:0000255"
FT   MOD_RES         174
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R143"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        17..22
FT                   /note="Missing (in Ref. 1; CAH90188)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        116
FT                   /note="Missing (in Ref. 1; CAH89916)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="K -> R (in Ref. 1; CAI29677)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   180 AA;  20324 MW;  F1E66014D49EC1DE CRC64;
     MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSCLWC
     NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII TMSVVGGTLL LGIAICCCCC
     CRRKRSRKPD RSEEKAMRER EERRIRQEER RAEMKTRHDE IRKKYGLFKE ENPYARFENN