ID   PTTG_RAT                Reviewed;         174 AA.
AC   Q6P767;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Pituitary tumor-transforming gene 1 protein-interacting protein;
DE   AltName: Full=Pituitary tumor-transforming gene protein-binding factor;
DE            Short=PBF;
DE            Short=PTTG-binding factor;
DE   Flags: Precursor;
GN   Name=Pttg1ip;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May facilitate PTTG1 nuclear translocation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PTTG1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=May be cytoplasmic and nuclear. {ECO:0000250}.
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DR   EMBL; BC061813; AAH61813.1; -; mRNA.
DR   RefSeq; NP_001013256.1; NM_001013238.1.
DR   RefSeq; XP_006256315.1; XM_006256253.2.
DR   AlphaFoldDB; Q6P767; -.
DR   SMR; Q6P767; -.
DR   STRING; 10116.ENSRNOP00000001638; -.
DR   GlyGen; Q6P767; 2 sites.
DR   iPTMnet; Q6P767; -.
DR   PhosphoSitePlus; Q6P767; -.
DR   PaxDb; Q6P767; -.
DR   PRIDE; Q6P767; -.
DR   Ensembl; ENSRNOT00000001638; ENSRNOP00000001638; ENSRNOG00000001223.
DR   GeneID; 365548; -.
DR   KEGG; rno:365548; -.
DR   CTD; 754; -.
DR   RGD; 1305983; Pttg1ip.
DR   eggNOG; ENOG502RYM1; Eukaryota.
DR   GeneTree; ENSGT00390000004977; -.
DR   HOGENOM; CLU_109415_0_0_1; -.
DR   InParanoid; Q6P767; -.
DR   OMA; QNVACLW; -.
DR   OrthoDB; 1458076at2759; -.
DR   PhylomeDB; Q6P767; -.
DR   TreeFam; TF329310; -.
DR   PRO; PR:Q6P767; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000001223; Expressed in stomach and 19 other tissues.
DR   Genevisible; Q6P767; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002039; F:p53 binding; ISO:RGD.
DR   GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; ISO:RGD.
DR   GO; GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; ISO:RGD.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISO:RGD.
DR   GO; GO:0006606; P:protein import into nucleus; ISO:RGD.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR042492; PTTG1IP.
DR   PANTHER; PTHR15191:SF2; PTHR15191:SF2; 1.
DR   SMART; SM00423; PSI; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Cytoplasm; Glycoprotein; Membrane; Nucleus;
KW   Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..174
FT                   /note="Pituitary tumor-transforming gene 1 protein-
FT                   interacting protein"
FT                   /id="PRO_0000022187"
FT   TOPO_DOM        30..93
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..174
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..89
FT                   /note="PSI"
FT   REGION          126..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          127..163
FT                   /evidence="ECO:0000255"
FT   MOD_RES         171
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R143"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   174 AA;  19900 MW;  61B77EF9FF4CF85E CRC64;
     MASAVLGLTL RWVMFLSAVL LLLLPGASAQ EPPGVGCSEY TNRSCEECLR NVSCLWCNEN
     KACLDYPVRK ILPPASLCKL SSARWGVCWV NFEALIITMS VLGGSVLLGI TVCCCCCCRR
     KRSRKPDKSD ERAMREQEER RVRQEERRAE MKSRHDEIRK KYGLFKEQNP YEKF