PTX4_HUMAN
ID PTX4_HUMAN Reviewed; 478 AA.
AC Q96A99;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Pentraxin-4;
DE Flags: Precursor;
GN Name=PTX4; Synonyms=C16orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, AND INDUCTION.
RX PubMed=20357257; DOI=10.4049/jimmunol.0901672;
RA Martinez de la Torre Y., Fabbri M., Jaillon S., Bastone A., Nebuloni M.,
RA Vecchi A., Mantovani A., Garlanda C.;
RT "Evolution of the pentraxin family: the new entry PTX4.";
RL J. Immunol. 184:5055-5064(2010).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2; Synonyms=PTX4(2);
CC IsoId=Q96A99-1; Sequence=Displayed;
CC Name=1; Synonyms=PTX4(1), Long;
CC IsoId=Q96A99-2; Sequence=VSP_040203;
CC -!- TISSUE SPECIFICITY: Widely expressed at low levels with highest levels
CC in small intestine, testis and brain. Very low expression in
CC endothelial cells, monocytes, neutrophils and lymphocytes. Isoform 1 is
CC not expressed in small intestine. {ECO:0000269|PubMed:20357257}.
CC -!- INDUCTION: Not induced by bacterial lipopolysaccharideS (LPS) or
CC IL1/interleukin-1 in endothelium, monocytes or neutrophils. Not induced
CC by PHA in lymphocytes. {ECO:0000269|PubMed:20357257}.
CC -!- MISCELLANEOUS: [Isoform 1]: Not expressed in small intestine.
CC {ECO:0000305|PubMed:20357257}.
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DR EMBL; AL031705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AE006467; AAK61283.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85652.1; -; Genomic_DNA.
DR EMBL; BC156066; AAI56067.1; -; mRNA.
DR EMBL; BC156944; AAI56945.1; -; mRNA.
DR CCDS; CCDS32362.1; -. [Q96A99-2]
DR CCDS; CCDS86492.1; -. [Q96A99-1]
DR RefSeq; NP_001013680.1; NM_001013658.1. [Q96A99-2]
DR RefSeq; NP_001315537.1; NM_001328608.1. [Q96A99-1]
DR AlphaFoldDB; Q96A99; -.
DR SMR; Q96A99; -.
DR BioGRID; 133654; 52.
DR IntAct; Q96A99; 1.
DR STRING; 9606.ENSP00000293922; -.
DR GlyGen; Q96A99; 2 sites.
DR BioMuta; PTX4; -.
DR DMDM; 189042530; -.
DR MassIVE; Q96A99; -.
DR PaxDb; Q96A99; -.
DR PeptideAtlas; Q96A99; -.
DR PRIDE; Q96A99; -.
DR ProteomicsDB; 75939; -. [Q96A99-1]
DR ProteomicsDB; 75940; -. [Q96A99-2]
DR Antibodypedia; 67891; 15 antibodies from 8 providers.
DR DNASU; 390667; -.
DR Ensembl; ENST00000293922.1; ENSP00000293922.1; ENSG00000251692.8. [Q96A99-2]
DR Ensembl; ENST00000447419.7; ENSP00000445277.2; ENSG00000251692.8. [Q96A99-1]
DR GeneID; 390667; -.
DR KEGG; hsa:390667; -.
DR MANE-Select; ENST00000447419.7; ENSP00000445277.2; NM_001328608.2; NP_001315537.1.
DR UCSC; uc010uvf.2; human. [Q96A99-1]
DR CTD; 390667; -.
DR DisGeNET; 390667; -.
DR GeneCards; PTX4; -.
DR HGNC; HGNC:14171; PTX4.
DR HPA; ENSG00000251692; Tissue enhanced (brain).
DR MIM; 613442; gene.
DR neXtProt; NX_Q96A99; -.
DR OpenTargets; ENSG00000251692; -.
DR PharmGKB; PA25553; -.
DR VEuPathDB; HostDB:ENSG00000251692; -.
DR eggNOG; ENOG502QTID; Eukaryota.
DR GeneTree; ENSGT01050000244805; -.
DR HOGENOM; CLU_044996_0_0_1; -.
DR InParanoid; Q96A99; -.
DR OMA; MGCLWRK; -.
DR OrthoDB; 770812at2759; -.
DR PhylomeDB; Q96A99; -.
DR TreeFam; TF330208; -.
DR PathwayCommons; Q96A99; -.
DR SignaLink; Q96A99; -.
DR BioGRID-ORCS; 390667; 12 hits in 1067 CRISPR screens.
DR GenomeRNAi; 390667; -.
DR Pharos; Q96A99; Tdark.
DR PRO; PR:Q96A99; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96A99; protein.
DR Bgee; ENSG00000251692; Expressed in leukocyte and 49 other tissues.
DR ExpressionAtlas; Q96A99; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00152; PTX; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Disulfide bond; Glycoprotein; Metal-binding;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..478
FT /note="Pentraxin-4"
FT /id="PRO_0000320645"
FT DOMAIN 269..473
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT REGION 208..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 322
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 323
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 406
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 406
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 407
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 408
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 408
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 300..364
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT VAR_SEQ 1..47
FT /note="MGCSWRKTLSFFLVFVPIYLHGASSQEAAPVGPRKPFFERLRRLEEQ -> M
FT GSGNWEVTGPPCGSRCERPPGLPRGVHGQFRSAVGLSGLRW (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040203"
FT VARIANT 2
FT /note="G -> E (in dbSNP:rs2745103)"
FT /id="VAR_060084"
FT VARIANT 92
FT /note="R -> W (in dbSNP:rs2745101)"
FT /id="VAR_039249"
FT VARIANT 220
FT /note="R -> G (in dbSNP:rs2667673)"
FT /id="VAR_039250"
FT VARIANT 234
FT /note="R -> Q (in dbSNP:rs12445920)"
FT /id="VAR_039251"
FT VARIANT 281
FT /note="R -> K (in dbSNP:rs2745098)"
FT /id="VAR_039252"
FT VARIANT 317
FT /note="A -> S (in dbSNP:rs13332460)"
FT /id="VAR_039253"
FT VARIANT 444
FT /note="I -> V (in dbSNP:rs59554810)"
FT /id="VAR_062130"
SQ SEQUENCE 478 AA; 52339 MW; 2404908AB8A01F60 CRC64;
MGCSWRKTLS FFLVFVPIYL HGASSQEAAP VGPRKPFFER LRRLEEQFRR FQEVTWTHLQ
NIASNYNVSY NVDVRFRSLA EESQAVAQAV NRSQASVQGE LAQLKAWVRK LQRRGRKVDT
RLRALDLTLG ERSQQRARER KAHKAQRDAL QDSLARLEGL VHSQGARLAA LEGRLPVAHP
GTAALGPALV PTPTQPEELG PTSLKLQRDR QELRAASEHR GPPQDSSAPL QGRREPPASG
SHRVLSGTAP KDPRQQAWSP QVPGEICGVG PTLVFPNAST RNVVFLSPGF VTALRALSFC
SWVRTASGRL GTLLSYATED NDNKLVLHGR DSLLPGSIHF VIGDPAFREL PLQLLLDGQW
HHICVIWTST QGRYWLHVDR RLVATGSRFR EGYEIPPGGS LVLGQEQDSV GGGFDSSEAF
VGSMSGLAIW DRALVPGEVA NLAIGKEFPT GAILTLANAA LAGGFVQGAN CTCLERCP
