ID   PTXA_PSEST              Reviewed;         275 AA.
AC   O69051;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Phosphite import ATP-binding protein PxtA;
DE            EC=7.6.2.-;
GN   Name=ptxA;
OS   Pseudomonas stutzeri (Pseudomonas perfectomarina).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=316 {ECO:0000312|EMBL:AAC71706.1};
RN   [1] {ECO:0000312|EMBL:AAC71706.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=WM88;
RX   PubMed=9791102; DOI=10.1128/jb.180.21.5547-5558.1998;
RA   Metcalf W.W., Wolfe R.S.;
RT   "Molecular genetic analysis of phosphite and hypophosphite oxidation by
RT   Pseudomonas stutzeri WM88.";
RL   J. Bacteriol. 180:5547-5558(1998).
RN   [2]
RP   FUNCTION.
RC   STRAIN=WM88;
RX   PubMed=15231805; DOI=10.1128/jb.186.14.4730-4739.2004;
RA   White A.K., Metcalf W.W.;
RT   "Two C-P lyase operons in Pseudomonas stutzeri and their roles in the
RT   oxidation of phosphonates, phosphite, and hypophosphite.";
RL   J. Bacteriol. 186:4730-4739(2004).
CC   -!- FUNCTION: Part of the ABC transporter complex PtxABC involved in
CC       phosphite import. Responsible for energy coupling to the transport
CC       system (Probable). {ECO:0000305|PubMed:15231805,
CC       ECO:0000305|PubMed:9791102}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + phosphite(out) = ADP + H(+) + phosphate +
CC         phosphite(in); Xref=Rhea:RHEA:48972, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36361,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (PtxA),
CC       two transmembrane proteins (PtxC) and a solute-binding protein (PtxB).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Phosphonates
CC       importer (TC 3.A.1.9.1) family. {ECO:0000305}.
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DR   EMBL; AF061070; AAC71706.1; -; Genomic_DNA.
DR   RefSeq; WP_003118432.1; NZ_RHQY01000096.1.
DR   AlphaFoldDB; O69051; -.
DR   SMR; O69051; -.
DR   OrthoDB; 1181903at2; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015416; F:ABC-type phosphonate transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03256; ABC_PhnC_transporter; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR012693; ABC_transpr_PhnC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02315; ABC_phnC; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51249; PHNC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..275
FT                   /note="Phosphite import ATP-binding protein PxtA"
FT                   /id="PRO_0000092954"
FT   DOMAIN          11..252
FT                   /note="ABC transporter"
FT   REGION          251..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   275 AA;  29649 MW;  CC057CBE25A5B6BB CRC64;
     MTPHPIQDAV LRVDRLSVVY PGGVTALRDT SIAFRRGEFT VLLGLSGAGK STLLRSLNRL
     VTPTGGSVTS ELGELGSGSA LRQHRRRTAM IFQHHQLIER QSALANVLTG RLAFHNTLRS
     LFPLPRADQE IALSCLARVG LADKALSRVD KLSGGQQQRV GIARALAQQP AIILADEPVA
     SLDPATSVRV LGLLRDICKE DGITAIVSLH QLEYARRFAD RVVGLADSQI VFDAAPSELT
     DAQLERIYAG RSTTQPANAP AEPPVMLEPS LEMSR