ID   PTYA_LITSE              Reviewed;          18 AA.
AC   P84815;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Peptide tyrosine arginine;
OS   Lithobates sevosus (Dusky gopher frog) (Rana sevosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=299683;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AMIDATION AT ARG-18, FUNCTION, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:15808903};
RX   PubMed=15808903; DOI=10.1016/j.peptides.2004.12.006;
RA   Graham C., Irvine A.E., McClean S., Richter S.C., Flatt P.R., Shaw C.;
RT   "Peptide tyrosine arginine, a potent immunomodulatory peptide isolated and
RT   structurally characterized from the skin secretions of the dusky gopher
RT   frog, Rana sevosa.";
RL   Peptides 26:737-743(2005).
CC   -!- FUNCTION: Mast cell degranulating peptide. Inhibits granulopoiesis in
CC       human bone marrow in vitro. Causes histamine release from rat
CC       peritoneal mast cells in vitro. Does not induce apoptosis of human
CC       neutrophils in vitro. {ECO:0000269|PubMed:15808903}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15808903}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:15808903}.
CC   -!- MASS SPECTROMETRY: Mass=2160; Method=Plasma desorption;
CC       Evidence={ECO:0000269|PubMed:15808903};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P84815; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IDA:UniProtKB.
DR   InterPro; IPR032019; Frog_antimicrobial_Ranidae.
DR   Pfam; PF16048; Antimicrobial23; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Inflammatory response; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..18
FT                   /note="Peptide tyrosine arginine"
FT                   /evidence="ECO:0000269|PubMed:15808903"
FT                   /id="PRO_0000235910"
FT   MOD_RES         18
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000269|PubMed:15808903"
FT   DISULFID        5..15
FT                   /evidence="ECO:0000250|UniProtKB:Q90WP7"
SQ   SEQUENCE   18 AA;  2162 MW;  AF3015D9E0FAFFB4 CRC64;
     YLKGCWTKSY PPKPCFSR