PUB11_ARATH
ID PUB11_ARATH Reviewed; 612 AA.
AC Q8GUG9; O23121; Q56WV7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=U-box domain-containing protein 11;
DE EC=2.3.2.27;
DE AltName: Full=Plant U-box protein 11;
DE AltName: Full=RING-type E3 ubiquitin transferase PUB11 {ECO:0000305};
GN Name=PUB11; OrderedLocusNames=At1g23030; ORFNames=F10G19.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-612.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=11495788; DOI=10.1016/s1360-1385(01)01960-4;
RA Azevedo C., Santos-Rosa M.J., Shirasu K.;
RT "The U-box protein family in plants.";
RL Trends Plant Sci. 6:354-358(2001).
RN [6]
RP GENE FAMILY ORGANIZATION.
RX PubMed=14657406; DOI=10.1104/pp.103.029553;
RA Mudgil Y., Shiu S.-H., Stone S.L., Salt J.N., Goring D.R.;
RT "A large complement of the predicted Arabidopsis ARM repeat proteins are
RT members of the U-box E3 ubiquitin ligase family.";
RL Plant Physiol. 134:59-66(2004).
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB72157.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF000657; AAB72157.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30324.1; -; Genomic_DNA.
DR EMBL; BT002518; AAO00878.1; -; mRNA.
DR EMBL; AK221923; BAD94341.1; -; mRNA.
DR PIR; D86364; D86364.
DR RefSeq; NP_173716.1; NM_102151.5.
DR AlphaFoldDB; Q8GUG9; -.
DR SMR; Q8GUG9; -.
DR STRING; 3702.AT1G23030.1; -.
DR PaxDb; Q8GUG9; -.
DR PRIDE; Q8GUG9; -.
DR EnsemblPlants; AT1G23030.1; AT1G23030.1; AT1G23030.
DR GeneID; 838911; -.
DR Gramene; AT1G23030.1; AT1G23030.1; AT1G23030.
DR KEGG; ath:AT1G23030; -.
DR Araport; AT1G23030; -.
DR TAIR; locus:2017719; AT1G23030.
DR eggNOG; KOG0167; Eukaryota.
DR HOGENOM; CLU_006348_5_1_1; -.
DR InParanoid; Q8GUG9; -.
DR OMA; GYINGRT; -.
DR OrthoDB; 308896at2759; -.
DR PhylomeDB; Q8GUG9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q8GUG9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GUG9; baseline and differential.
DR Genevisible; Q8GUG9; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:TAIR.
DR GO; GO:0051865; P:protein autoubiquitination; IDA:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IDA:TAIR.
DR GO; GO:0090333; P:regulation of stomatal closure; IMP:TAIR.
DR CDD; cd16664; RING-Ubox_PUB; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045210; RING-Ubox_PUB.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00185; ARM; 5.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51698; U_BOX; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; Repeat; Transferase;
KW Ubl conjugation pathway.
FT CHAIN 1..612
FT /note="U-box domain-containing protein 11"
FT /id="PRO_0000322156"
FT DOMAIN 240..314
FT /note="U-box"
FT REPEAT 363..402
FT /note="ARM 1"
FT REPEAT 404..443
FT /note="ARM 2"
FT REPEAT 445..484
FT /note="ARM 3"
FT REPEAT 486..526
FT /note="ARM 4"
FT REPEAT 528..567
FT /note="ARM 5"
FT COILED 127..196
FT /evidence="ECO:0000255"
FT CONFLICT 67
FT /note="W -> C (in Ref. 3; AAO00878)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 612 AA; 67356 MW; E0C2963C7953CF82 CRC64;
MAGGIVSPAS LLDLIADIVE IPLNTGMFKK DCADLTRRVC LLTHLLEEIR DSTPIDSAAS
SSSENDWWSD LVVGLQAAKR LLSTARFQAR DSSDGAAKRI SFQFQCVTWK LEKALSNLPY
DLYDISDEVG EQVELARSQL RRAMQRYGSL NSNKFSSALS EPMERDGFSN VIKIKAEEKL
ESVSETLHFG EEEEKQSSPP LRRSSSISLA YYLSKDADTD RLDKMVNKNT DESKKSDKLT
IPVDFLCPVS LELMKDPVIV ATGQTYERAY IQRWIDCGNL TCPKTQQKLE NFTLTPNYVL
RSLISRWCAE HNIEQPAGYI NGRTKNSGDM SVIRALVQRL SSRSTEDRRN AVSEIRSLSK
RSTDNRILIA EAGAIPVLVN LLTSEDVATQ ENAITCVLNL SIYENNKELI MFAGAVTSIV
QVLRAGTMEA RENAAATLFS LSLADENKII IGGSGAIPAL VDLLENGTPR GKKDAATALF
NLCIYHGNKG RAVRAGIVTA LVKMLSDSTR HRMVDEALTI LSVLANNQDA KSAIVKANTL
PALIGILQTD QTRNRENAAA ILLSLCKRDT EKLITIGRLG AVVPLMDLSK NGTERGKRKA
ISLLELLRKA CQ