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PUB12_ORYSJ
ID   PUB12_ORYSJ             Reviewed;         611 AA.
AC   Q5VRH9; Q5VRH8;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=U-box domain-containing protein 12;
DE            EC=2.3.2.27;
DE   AltName: Full=Plant U-box protein 12;
DE            Short=OsPUB12;
DE   AltName: Full=RING-type E3 ubiquitin transferase PUB12 {ECO:0000305};
GN   Name=PUB12; OrderedLocusNames=Os06g0102700, LOC_Os06g01304;
GN   ORFNames=OSJNBa0075G19.19-1;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19825583; DOI=10.1093/mp/ssn044;
RA   Zeng L.R., Park C.H., Venu R.C., Gough J., Wang G.L.;
RT   "Classification, expression pattern, and E3 ligase activity assay of rice
RT   U-box-containing proteins.";
RL   Mol. Plant 1:800-815(2008).
CC   -!- FUNCTION: Possesses E3 ubiquitin-protein ligase in vitro.
CC       {ECO:0000269|PubMed:19825583}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5VRH9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5VRH9-2; Sequence=VSP_039692;
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DR   EMBL; AP002842; BAD67946.1; -; Genomic_DNA.
DR   EMBL; AP002842; BAD67947.1; -; Genomic_DNA.
DR   EMBL; AP008212; BAF18449.2; -; Genomic_DNA.
DR   EMBL; AP014962; BAS95707.1; -; Genomic_DNA.
DR   EMBL; AK067611; BAG90500.1; -; mRNA.
DR   EMBL; AK071080; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015643776.1; XM_015788290.1. [Q5VRH9-1]
DR   RefSeq; XP_015643777.1; XM_015788291.1. [Q5VRH9-1]
DR   AlphaFoldDB; Q5VRH9; -.
DR   SMR; Q5VRH9; -.
DR   STRING; 4530.OS06T0102700-01; -.
DR   PaxDb; Q5VRH9; -.
DR   PRIDE; Q5VRH9; -.
DR   EnsemblPlants; Os06t0102700-01; Os06t0102700-01; Os06g0102700. [Q5VRH9-2]
DR   GeneID; 4339839; -.
DR   Gramene; Os06t0102700-01; Os06t0102700-01; Os06g0102700. [Q5VRH9-2]
DR   KEGG; osa:4339839; -.
DR   eggNOG; KOG0167; Eukaryota.
DR   HOGENOM; CLU_006348_5_1_1; -.
DR   InParanoid; Q5VRH9; -.
DR   OMA; TGSMETR; -.
DR   OrthoDB; 389393at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   Genevisible; Q5VRH9; OS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
DR   CDD; cd16664; RING-Ubox_PUB; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045210; RING-Ubox_PUB.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00514; Arm; 3.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00185; ARM; 5.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Repeat; Transferase;
KW   Ubl conjugation pathway.
FT   CHAIN           1..611
FT                   /note="U-box domain-containing protein 12"
FT                   /id="PRO_0000397690"
FT   DOMAIN          227..301
FT                   /note="U-box"
FT   REPEAT          355..394
FT                   /note="ARM 1"
FT   REPEAT          396..435
FT                   /note="ARM 2"
FT   REPEAT          437..476
FT                   /note="ARM 3"
FT   REPEAT          478..517
FT                   /note="ARM 4"
FT   VAR_SEQ         604..611
FT                   /note="DSLKGNGH -> A (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12869764"
FT                   /id="VSP_039692"
FT   CONFLICT        62
FT                   /note="L -> I (in Ref. 4; AK071080)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   611 AA;  66241 MW;  F982EF57A81E376F CRC64;
     MPKRVADEIA ALPEPRGPLR RPCADLSRRV RLLAPLLDHL PASSSSSSST PLADALGAAR
     DLLRKTRDGS KIDQAMRGDA FLDEFAGVNR QIHLALDALP YNTFHMPQEV QEQVALVHSQ
     FQRASTRTDP PDTQLSMDLA WALTDNPSDP ALLTRISHKL QLHTMADMKN ESIALHNMVI
     STAGEPDGCV DQMSSLLKKL KDCVVTEDHA NDALTTRSAS IKHRSPIIPD EFRCPISLEL
     MQDPVIVSSG QTYERSCIQK WLDSGHKTCP KTQQPLSHTS LTPNFVLKSL ISQWCEANGI
     ELPKNKQNSR DKKAAKSSDY DHAGLVSLMN RLRSGNQDEQ RAAAGEIRLL AKRNVNNRIC
     IAEAGAIPLL VNLLSSSDPR TQEHAVTALL NLSIHENNKA SIVDSHAIPK IVEVLKTGSM
     ETRENAAATL FSLSVVDENK VTIGAAGAIP PLINLLCDGS PRGKKDAATA IFNLCIYQGN
     KVRAVKAGIV IHLMNFLVDP TGGMIDEALS LLSILAGNPE GKIVIARSEP IPPLVEVIKT
     GSPRNRENAA AILWLLCSAD TEQTLAAKAA GVEDALKELS ETGTDRAKRK ASSILELMHQ
     ANEDSLKGNG H
 
 
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