PUB17_ARATH
ID PUB17_ARATH Reviewed; 729 AA.
AC Q9C7R6; Q8VZK7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=U-box domain-containing protein 17;
DE EC=2.3.2.27;
DE AltName: Full=Plant U-box protein 17;
DE AltName: Full=RING-type E3 ubiquitin transferase PUB17 {ECO:0000305};
GN Name=PUB17; OrderedLocusNames=At1g29340; ORFNames=F15D2.34;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=11495788; DOI=10.1016/s1360-1385(01)01960-4;
RA Azevedo C., Santos-Rosa M.J., Shirasu K.;
RT "The U-box protein family in plants.";
RL Trends Plant Sci. 6:354-358(2001).
RN [5]
RP GENE FAMILY ORGANIZATION.
RX PubMed=14657406; DOI=10.1104/pp.103.029553;
RA Mudgil Y., Shiu S.-H., Stone S.L., Salt J.N., Goring D.R.;
RT "A large complement of the predicted Arabidopsis ARM repeat proteins are
RT members of the U-box E3 ubiquitin ligase family.";
RL Plant Physiol. 134:59-66(2004).
RN [6]
RP FUNCTION.
RX PubMed=16531496; DOI=10.1105/tpc.105.039198;
RA Yang C.-W., Gonzalez-Lamothe R., Ewan R.A., Rowland O., Yoshioka H.,
RA Shenton M., Ye H., O'Donnell E., Jones J.D.G., Sadanandom A.;
RT "The E3 ubiquitin ligase activity of arabidopsis PLANT U-BOX17 and its
RT functional tobacco homolog ACRE276 are required for cell death and
RT defense.";
RL Plant Cell 18:1084-1098(2006).
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC {ECO:0000269|PubMed:16531496}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
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DR EMBL; AC068667; AAG51726.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31074.1; -; Genomic_DNA.
DR EMBL; AY064045; AAL36401.1; -; mRNA.
DR EMBL; AY150512; AAN13028.1; -; mRNA.
DR PIR; A86416; A86416.
DR RefSeq; NP_174228.1; NM_102674.4.
DR AlphaFoldDB; Q9C7R6; -.
DR SMR; Q9C7R6; -.
DR IntAct; Q9C7R6; 1.
DR STRING; 3702.AT1G29340.1; -.
DR PaxDb; Q9C7R6; -.
DR PRIDE; Q9C7R6; -.
DR ProteomicsDB; 224849; -.
DR EnsemblPlants; AT1G29340.1; AT1G29340.1; AT1G29340.
DR GeneID; 839808; -.
DR Gramene; AT1G29340.1; AT1G29340.1; AT1G29340.
DR KEGG; ath:AT1G29340; -.
DR Araport; AT1G29340; -.
DR TAIR; locus:2013688; AT1G29340.
DR eggNOG; KOG0167; Eukaryota.
DR HOGENOM; CLU_006348_5_2_1; -.
DR InParanoid; Q9C7R6; -.
DR OMA; THTDNCV; -.
DR OrthoDB; 528081at2759; -.
DR PhylomeDB; Q9C7R6; -.
DR BRENDA; 2.3.2.27; 399.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9C7R6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C7R6; baseline and differential.
DR Genevisible; Q9C7R6; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:TAIR.
DR GO; GO:0098542; P:defense response to other organism; IMP:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IDA:TAIR.
DR CDD; cd16664; RING-Ubox_PUB; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045210; RING-Ubox_PUB.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00514; Arm; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00185; ARM; 5.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Transferase; Ubl conjugation pathway.
FT CHAIN 1..729
FT /note="U-box domain-containing protein 17"
FT /id="PRO_0000322161"
FT DOMAIN 304..378
FT /note="U-box"
FT REPEAT 438..477
FT /note="ARM 1"
FT REPEAT 479..520
FT /note="ARM 2"
FT REPEAT 523..562
FT /note="ARM 3"
FT REPEAT 564..601
FT /note="ARM 4"
FT CONFLICT 571
FT /note="I -> T (in Ref. 3; AAL36401)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 729 AA; 79834 MW; 206F96A0C6E9E482 CRC64;
MASAAIFSSL RRRRSPSLEA FLAPVDLSGV ALVQTLASIS SEVVSCFTSV RFSFQRKNAR
SLIRKIEIFV VLFEFLVDSN WGSTTTRTRA RRRSKSSVSE STALLCLKEL YLLLYRSKIL
VDYCAQSSKL WLLLQNPSIS GYFHDLNQEI STLLDVLPVN DLGLSDDIRE QIELLQRQSR
KARLYIDKND ESLRESFYSF LDGFENGKIP SSVDLRMFFV EKLGIRDSKS CRSEIEFLEE
QIVNHDGDLE PTGSVINGFV AITRYCRFLL FGFEEDGMEW WIENNPKKPR KGFVAQEIGD
TFITVPKDFV CPISLDLMTD PVIISTGQTY DRNSIARWIE EGHCTCPKTG QMLMDSRIVP
NRALKNLIVQ WCTASGISYE SEFTDSPNES FASALPTKAA VEANKATVSI LIKYLADGSQ
AAQTVAAREI RLLAKTGKEN RAYIAEAGAI PHLCRLLTSE NAIAQENSVT AMLNLSIYEK
NKSRIMEEGD CLESIVSVLV SGLTVEAQEN AAATLFSLSA VHEYKKRIAI VDQCVEALAL
LLQNGTPRGK KDAVTALYNL STHPDNCSRM IEGGGVSSLV GALKNEGVAE EAAGALALLV
RQSLGAEAIG KEDSAVAGLM GMMRCGTPRG KENAVAALLE LCRSGGAAVA EKVLRAPAIA
GLLQTLLFTG TKRARRKAAS LARVFQRREN AAMRSGVYGF VGNTNGNRDG GFTTDVSVPI
SISISVPVL
