位置:首页 > 蛋白库 > PUB24_ARATH
PUB24_ARATH
ID   PUB24_ARATH             Reviewed;         456 AA.
AC   Q9SF15; B9DGA6; F4J7H3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=E3 ubiquitin-protein ligase PUB24;
DE            EC=2.3.2.27;
DE   AltName: Full=Plant U-box protein 24;
DE   AltName: Full=RING-type E3 ubiquitin transferase PUB24 {ECO:0000305};
DE   AltName: Full=U-box domain-containing protein 24;
GN   Name=PUB24; OrderedLocusNames=At3g11840; ORFNames=F26K24.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA   Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA   Shinozaki K.;
RT   "Analysis of multiple occurrences of alternative splicing events in
RT   Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL   DNA Res. 16:155-164(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX   PubMed=11495788; DOI=10.1016/s1360-1385(01)01960-4;
RA   Azevedo C., Santos-Rosa M.J., Shirasu K.;
RT   "The U-box protein family in plants.";
RL   Trends Plant Sci. 6:354-358(2001).
RN   [7]
RP   GENE FAMILY ORGANIZATION.
RX   PubMed=14657406; DOI=10.1104/pp.103.029553;
RA   Mudgil Y., Shiu S.-H., Stone S.L., Salt J.N., Goring D.R.;
RT   "A large complement of the predicted Arabidopsis ARM repeat proteins are
RT   members of the U-box E3 ubiquitin ligase family.";
RL   Plant Physiol. 134:59-66(2004).
RN   [8]
RP   FUNCTION, INDUCTION, AUTOUBIQUITINATION, AND MUTAGENESIS OF CYS-16 AND
RP   TRP-43.
RX   PubMed=18771922; DOI=10.1016/j.cub.2008.07.085;
RA   Trujillo M., Ichimura K., Casais C., Shirasu K.;
RT   "Negative regulation of PAMP-triggered immunity by an E3 ubiquitin ligase
RT   triplet in Arabidopsis.";
RL   Curr. Biol. 18:1396-1401(2008).
CC   -!- FUNCTION: E3 ubiquitin-protein ligase that acts as negative regulator
CC       of the immunity triggered by the pathogen-associated molecular patterns
CC       (PAMPs), in association with PUB22 and PUB23.
CC       {ECO:0000269|PubMed:18771922}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- INDUCTION: By the bacterial elicitor flg22, and bacterial and oomycete
CC       pathogens. {ECO:0000269|PubMed:18771922}.
CC   -!- PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:18771922}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAH19773.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC016795; AAF23200.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75107.2; -; Genomic_DNA.
DR   EMBL; AK228955; BAF00844.1; -; mRNA.
DR   EMBL; AK317081; BAH19773.1; ALT_INIT; mRNA.
DR   EMBL; AY084238; AAM67265.1; -; mRNA.
DR   RefSeq; NP_566402.2; NM_112017.4.
DR   AlphaFoldDB; Q9SF15; -.
DR   SMR; Q9SF15; -.
DR   STRING; 3702.AT3G11840.1; -.
DR   PaxDb; Q9SF15; -.
DR   PRIDE; Q9SF15; -.
DR   ProteomicsDB; 226253; -.
DR   EnsemblPlants; AT3G11840.1; AT3G11840.1; AT3G11840.
DR   GeneID; 820357; -.
DR   Gramene; AT3G11840.1; AT3G11840.1; AT3G11840.
DR   KEGG; ath:AT3G11840; -.
DR   Araport; AT3G11840; -.
DR   eggNOG; ENOG502SC8Q; Eukaryota.
DR   HOGENOM; CLU_006348_1_0_1; -.
DR   InParanoid; Q9SF15; -.
DR   OMA; VNCFEEI; -.
DR   OrthoDB; 666272at2759; -.
DR   PhylomeDB; Q9SF15; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9SF15; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SF15; baseline and differential.
DR   Genevisible; Q9SF15; AT.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045185; PUB22/23/24-like.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22849; PTHR22849; 1.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   1: Evidence at protein level;
KW   Plant defense; Reference proteome; Repeat; Transferase; Ubl conjugation;
KW   Ubl conjugation pathway.
FT   CHAIN           1..456
FT                   /note="E3 ubiquitin-protein ligase PUB24"
FT                   /id="PRO_0000322168"
FT   DOMAIN          9..83
FT                   /note="U-box"
FT   MUTAGEN         16
FT                   /note="C->A: Loss of autoubiquitination."
FT                   /evidence="ECO:0000269|PubMed:18771922"
FT   MUTAGEN         43
FT                   /note="W->A: Loss of autoubiquitination."
FT                   /evidence="ECO:0000269|PubMed:18771922"
SQ   SEQUENCE   456 AA;  51287 MW;  509873CAC065BB8D CRC64;
     MDQEEEEIEI PNYFICPISL EIMKDPVTTV SGITYDRQNI VKWLEKVPSC PVTKQPLPLD
     SDLTPNHMLR RLIQHWCVEN ETRGVVRIST PRVPPGKLNV VEEIKNLKKF GQEALGREET
     LQKLEVLAMD GNNRRLMCEC GVHKSLILFV VKCTSEDEDG RRRIKGLDES LRLLHLIGIP
     SNDAKTILME NDRVMESLTW VLHQEDFLSK AYTIVLLRNL TEYTSSHIVE RLNPEIFKGI
     IGFLKDVVNS VNRTSPTVRE TVQSSSRPSL GKTEPSKLDH SLVIKQAVTA ALMILLETSS
     WSRNRSLLVD LGAVSELIEL EISYTGEKRI TELMLGVLSR LCCCANGRAE ILAHRGGIAV
     VTKRLLRVSP AADDRAISIL TTVSKFSPEN MVVEEMVNVG TVEKLCSVLG MDCGLNLKEK
     AKEILKDHFD EWKKFPCIDI TLLTKLLSIS PKGPKI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024