ID   PUB26_ARATH             Reviewed;         421 AA.
AC   Q9FXA4; Q8GXA0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=U-box domain-containing protein 26;
DE            EC=2.3.2.27;
DE   AltName: Full=Plant U-box protein 26;
DE   AltName: Full=RING-type E3 ubiquitin transferase PUB26 {ECO:0000305};
GN   Name=PUB26; OrderedLocusNames=At1g49780; ORFNames=F14J22.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX   PubMed=11495788; DOI=10.1016/s1360-1385(01)01960-4;
RA   Azevedo C., Santos-Rosa M.J., Shirasu K.;
RT   "The U-box protein family in plants.";
RL   Trends Plant Sci. 6:354-358(2001).
RN   [6]
RP   GENE FAMILY ORGANIZATION.
RX   PubMed=14657406; DOI=10.1104/pp.103.029553;
RA   Mudgil Y., Shiu S.-H., Stone S.L., Salt J.N., Goring D.R.;
RT   "A large complement of the predicted Arabidopsis ARM repeat proteins are
RT   members of the U-box E3 ubiquitin ligase family.";
RL   Plant Physiol. 134:59-66(2004).
CC   -!- FUNCTION: Functions as an E3 ubiquitin ligase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
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DR   EMBL; AC011807; AAG13057.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32475.1; -; Genomic_DNA.
DR   EMBL; AK118346; BAC42960.1; -; mRNA.
DR   EMBL; BT029013; ABI93922.1; -; mRNA.
DR   PIR; E96534; E96534.
DR   RefSeq; NP_175400.1; NM_103865.4.
DR   AlphaFoldDB; Q9FXA4; -.
DR   SMR; Q9FXA4; -.
DR   STRING; 3702.AT1G49780.1; -.
DR   PaxDb; Q9FXA4; -.
DR   PRIDE; Q9FXA4; -.
DR   ProteomicsDB; 226254; -.
DR   EnsemblPlants; AT1G49780.1; AT1G49780.1; AT1G49780.
DR   GeneID; 841401; -.
DR   Gramene; AT1G49780.1; AT1G49780.1; AT1G49780.
DR   KEGG; ath:AT1G49780; -.
DR   Araport; AT1G49780; -.
DR   TAIR; locus:2012136; AT1G49780.
DR   eggNOG; ENOG502QRXY; Eukaryota.
DR   HOGENOM; CLU_006348_1_1_1; -.
DR   InParanoid; Q9FXA4; -.
DR   OMA; DCWPEDS; -.
DR   OrthoDB; 1275246at2759; -.
DR   PhylomeDB; Q9FXA4; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9FXA4; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FXA4; baseline and differential.
DR   Genevisible; Q9FXA4; AT.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:TAIR.
DR   GO; GO:0098542; P:defense response to other organism; IMP:TAIR.
DR   GO; GO:0016567; P:protein ubiquitination; IDA:TAIR.
DR   CDD; cd16664; RING-Ubox_PUB; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045185; PUB22/23/24-like.
DR   InterPro; IPR045210; RING-Ubox_PUB.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22849; PTHR22849; 1.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..421
FT                   /note="U-box domain-containing protein 26"
FT                   /id="PRO_0000322170"
FT   DOMAIN          13..87
FT                   /note="U-box"
FT   CONFLICT        151
FT                   /note="R -> G (in Ref. 3; BAC42960)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        286
FT                   /note="A -> V (in Ref. 3; BAC42960)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  45963 MW;  59D2A867E9AA1C9A CRC64;
     MPGNLEPLDL GIQIPYHFRC PISLDLMSDP VTISTGQTYD RTSIDSWIAM GNTTCPVTRV
     ALSDFTLIPN HTLRRLIQEW CVANRSNGVE RIPTPKQPAD PISVRSLLSQ ASAITGTHVS
     VRSRAAAIRR LRGLARDSEK NRVLIAGHNA REILVRILFA DIETTSLSSE LVSESLALLV
     LLHMTETECE AVASDPSRVG FMTRLLFDSS IEIRVNAAAL IEMVLTGAKS MDLKLIISGS
     DSIFEGVLDL LKNPISSRRA LKIGIKAIFA LCLVKQTRHL AISAGAPGIL IDRLAADFDR
     CDTERGLATV ELLCRLPEGC AAFGEHALTV PLMVKTILRV SDRATEYAAG ALLALCTAEE
     RCRDEAAAAG LVTQLLLLVQ SDCTERAKRK AQMLLKLLRD SWPDDSTVHS DDFNRSEVAP
     F