PUB38_ARATH
ID PUB38_ARATH Reviewed; 556 AA.
AC Q9FJP6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=U-box domain-containing protein 38;
DE EC=2.3.2.27;
DE AltName: Full=Plant U-box protein 38;
DE AltName: Full=RING-type E3 ubiquitin transferase PUB38 {ECO:0000305};
GN Name=PUB38; OrderedLocusNames=At5g65200; ORFNames=MQN23.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY ORGANIZATION.
RX PubMed=14657406; DOI=10.1104/pp.103.029553;
RA Mudgil Y., Shiu S.-H., Stone S.L., Salt J.N., Goring D.R.;
RT "A large complement of the predicted Arabidopsis ARM repeat proteins are
RT members of the U-box E3 ubiquitin ligase family.";
RL Plant Physiol. 134:59-66(2004).
RN [5]
RP INTERACTION WITH SD16; SD17; SD18 AND SD129.
RX PubMed=18552232; DOI=10.1104/pp.108.123380;
RA Samuel M.A., Mudgil Y., Salt J.N., Delmas F., Ramachandran S., Chilelli A.,
RA Goring D.R.;
RT "Interactions between the S-domain receptor kinases and AtPUB-ARM E3
RT ubiquitin ligases suggest a conserved signaling pathway in Arabidopsis.";
RL Plant Physiol. 147:2084-2095(2008).
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Binds to SD16, SD17, SD18 and SD129.
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DR EMBL; AB013395; BAB11655.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98016.1; -; Genomic_DNA.
DR EMBL; BT015352; AAU05475.1; -; mRNA.
DR EMBL; BT015720; AAU45218.1; -; mRNA.
DR RefSeq; NP_201323.1; NM_125917.3.
DR AlphaFoldDB; Q9FJP6; -.
DR SMR; Q9FJP6; -.
DR BioGRID; 21885; 3.
DR STRING; 3702.AT5G65200.1; -.
DR iPTMnet; Q9FJP6; -.
DR PaxDb; Q9FJP6; -.
DR PRIDE; Q9FJP6; -.
DR ProteomicsDB; 224847; -.
DR EnsemblPlants; AT5G65200.1; AT5G65200.1; AT5G65200.
DR GeneID; 836643; -.
DR Gramene; AT5G65200.1; AT5G65200.1; AT5G65200.
DR KEGG; ath:AT5G65200; -.
DR Araport; AT5G65200; -.
DR TAIR; locus:2171810; AT5G65200.
DR eggNOG; ENOG502QPJU; Eukaryota.
DR HOGENOM; CLU_006348_7_0_1; -.
DR InParanoid; Q9FJP6; -.
DR OMA; HGSMRFR; -.
DR OrthoDB; 425663at2759; -.
DR PhylomeDB; Q9FJP6; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9FJP6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJP6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070696; F:transmembrane receptor protein serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IDA:TAIR.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00514; Arm; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00185; ARM; 4.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Transferase; Ubl conjugation pathway.
FT CHAIN 1..556
FT /note="U-box domain-containing protein 38"
FT /id="PRO_0000322178"
FT DOMAIN 32..108
FT /note="U-box"
FT REPEAT 256..295
FT /note="ARM 1"
FT REPEAT 297..336
FT /note="ARM 2"
FT REPEAT 338..378
FT /note="ARM 3"
FT REPEAT 380..417
FT /note="ARM 4"
FT REPEAT 418..468
FT /note="ARM 5"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 61778 MW; 34097C2FA2E0F2B1 CRC64;
MGKNGRLRWN PFSHRSSSST SSSSRQQQQE QQPPVEFLCP ISKSVMSDPV VVSSGQTFER
VCVQVCRDLN FIPKLNDDEE SLPDFSNIIP NLNMKSTIDT WCDTVGVSRP QPPDYSTVER
ILRQQMPPPD VEIRVSEQEL LRAVAHRAPM IIHHADSELM GRRDFNNSTT SSDESVIVAH
SPFTPLPLTT RPACFSPSPS SSSSEIETLT HHTFFSNSTS TATEEDEVIY NKLKSSEIFD
QEQGLIMMRK MTRTNDEARV SLCSPRILSL LKNMIVSRYS LVQTNALASL VNLSLDKKNK
LTIVRLGFVP ILIDVLKSGS REAQEHAAGT IFSLSLEDDN KMPIGVLGAL QPLLHALRAA
ESDRTRHDSA LALYHLTLNQ TNRSKLVRLG AVPALFSMVR SGESASRALL VICNLACCSE
GRSAMLDANA VAILVGKLRE EWTEEPTEAR SSSSARENCV AALFALSHES LRFKGLAKEA
RAVEVLKEVE ERGTERAREK AKKILQLMRE RVPEDDEEDG EGSIDWDRVI DSNGSIRSRF
RVGGRNRVVT QNSSGF
