ID   PUB57_ORYSJ             Reviewed;         518 AA.
AC   Q0DR28; A0A0P0VYX2; Q84MF6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=U-box domain-containing protein 57;
DE            EC=2.3.2.27;
DE   AltName: Full=Plant U-box protein 57;
DE            Short=OsPUB57;
DE   AltName: Full=RING-type E3 ubiquitin transferase PUB57 {ECO:0000305};
GN   Name=PUB57; OrderedLocusNames=Os03g0424200, LOC_Os03g31070;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19825583; DOI=10.1093/mp/ssn044;
RA   Zeng L.R., Park C.H., Venu R.C., Gough J., Wang G.L.;
RT   "Classification, expression pattern, and E3 ligase activity assay of rice
RT   U-box-containing proteins.";
RL   Mol. Plant 1:800-815(2008).
CC   -!- FUNCTION: Possesses E3 ubiquitin-protein ligase in vitro. May be
CC       involved in cell death signaling. {ECO:0000269|PubMed:19825583}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP20849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=ABF96696.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC114983; AAP20849.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000009; ABF96696.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008209; BAF12310.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS84766.1; -; Genomic_DNA.
DR   EMBL; AK069682; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q0DR28; -.
DR   SMR; Q0DR28; -.
DR   STRING; 4530.OS03T0424200-01; -.
DR   PaxDb; Q0DR28; -.
DR   PRIDE; Q0DR28; -.
DR   EnsemblPlants; Os03t0424200-01; Os03t0424200-01; Os03g0424200.
DR   Gramene; Os03t0424200-01; Os03t0424200-01; Os03g0424200.
DR   eggNOG; ENOG502QQ1P; Eukaryota.
DR   HOGENOM; CLU_000288_21_4_1; -.
DR   InParanoid; Q0DR28; -.
DR   OMA; WIVIEPL; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   Genevisible; Q0DR28; OS.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR024729; USP7_ICP0-binding_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF04564; U-box; 1.
DR   Pfam; PF12436; USP7_ICP0_bdg; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..518
FT                   /note="U-box domain-containing protein 57"
FT                   /id="PRO_0000397691"
FT   DOMAIN          159..409
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   DOMAIN          434..508
FT                   /note="U-box"
FT   COILED          86..142
FT                   /evidence="ECO:0000255"
FT   CONFLICT        41
FT                   /note="H -> R (in Ref. 5; AK069682)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        500
FT                   /note="G -> E (in Ref. 5; AK069682)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   518 AA;  58706 MW;  ED0E96C052A3663D CRC64;
     MQTGFSNSRM NSFISSVLVL HFNKQEIKFE PSVWCEAIDI HNTFSAGEII TGDIICFQKI
     LKPPDIPKYP SVASFLQHVC DRKTYEEVRK VHILEEEIVT LKHQADTYLV QKEKAVTAYD
     QLKHERDNAV QQVNELRDQS THIILDFSRK DMEQATEHFK NAREVGDTEY GHTYKGMIHN
     MKVLIKLSSS QKLFQQEVSI LRQWRHPNII TFIGVCSEVS ALVYEWLPNG NLEDRIICTN
     NSAPLSWYNR TQIIGEICCA LLFLHSNKST ALVHGDLRPC NILIDANYRS KICNFGMSNL
     FLQLGTFPPN LTARLPYMDP EFNTTGELTT LSDVYSLGVI ILRLLTGMPP LTLSEKVAEA
     LGSDSLHLLI DKSAGDWPYI EAKQLALIGL SCTGMTRKKR PDLLNEVWIV IEPLTRKPPA
     ATWPYLQSAS GDSSVPAAFI CPISMEIMKD PQVASDGFTY EAEAIRCWFD RGISRSPMTN
     LALPNLNLVP NRVLRSFIHG YLQQQQPNPA YQQQLSET