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PUB75_ORYSJ
ID   PUB75_ORYSJ             Reviewed;         459 AA.
AC   Q10PI9; Q0DTQ5; Q8S5X3;
DT   15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=U-box domain-containing protein 75 {ECO:0000305};
DE            Short=OsPUB75 {ECO:0000303|PubMed:19825583};
DE            EC=2.3.2.27 {ECO:0000305};
DE   AltName: Full=Protein ERECT LEAF 1 {ECO:0000303|PubMed:24299927};
DE   AltName: Full=Protein TAIHU DWARF1 {ECO:0000303|PubMed:23526892};
DE   AltName: Full=RING-type E3 ubiquitin transferase PUB75 {ECO:0000305};
GN   Name=TUD1 {ECO:0000303|PubMed:23526892};
GN   Synonyms=ELF1 {ECO:0000303|PubMed:24299927},
GN   PUB75 {ECO:0000303|PubMed:19825583};
GN   OrderedLocusNames=Os03g0232600 {ECO:0000312|EMBL:BAF11383.2},
GN   LOC_Os03g13010 {ECO:0000312|EMBL:ABF94807.1};
GN   ORFNames=OJ1175C11.15 {ECO:0000312|EMBL:AAM19135.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19825583; DOI=10.1093/mp/ssn044;
RA   Zeng L.R., Park C.H., Venu R.C., Gough J., Wang G.L.;
RT   "Classification, expression pattern, and E3 ligase activity assay of rice
RT   U-box-containing proteins.";
RL   Mol. Plant 1:800-815(2008).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24299927; DOI=10.4161/psb.27117;
RA   Sakamoto T., Kitano H., Fujioka S.;
RT   "An E3 ubiquitin ligase, ERECT LEAF1, functions in brassinosteroid
RT   signaling of rice.";
RL   Plant Signal. Behav. 8:E27117-E27117(2013).
RN   [8]
RP   FUNCTION, INTERACTION WITH GPA1, SUBCELLULAR LOCATION, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=23526892; DOI=10.1371/journal.pgen.1003391;
RA   Hu X., Qian Q., Xu T., Zhang Y., Dong G., Gao T., Xie Q., Xue Y.;
RT   "The U-box E3 ubiquitin ligase TUD1 functions with a heterotrimeric G alpha
RT   subunit to regulate Brassinosteroid-mediated growth in rice.";
RL   PLoS Genet. 9:E1003391-E1003391(2013).
CC   -!- FUNCTION: E3 ubiquitin ligase that may function as positive regulator
CC       of brassinosteroid (BR) signaling. Possesses E3 ubiquitin ligase in
CC       vitro (PubMed:24299927, PubMed:23526892). Acts together with the
CC       heterotrimeric G alpha subunit GPA1 at the plasma membrane to mediate a
CC       BR signaling pathway that affects plant growth and development. Does
CC       not seem to be involved in gibberellin or cytokinin responses
CC       (PubMed:23526892). {ECO:0000269|PubMed:23526892,
CC       ECO:0000269|PubMed:24299927}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000305};
CC   -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with GPA1. {ECO:0000269|PubMed:23526892}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23526892};
CC       Peripheral membrane protein {ECO:0000305|PubMed:23526892}.
CC   -!- TISSUE SPECIFICITY: Expressed highly in panicles at flowering time, at
CC       moderate levels in vegetative shoot apices, leaf sheaths, leaf blades,
CC       and elongating internodes, and at low levels in roots.
CC       {ECO:0000269|PubMed:24299927}.
CC   -!- INDUCTION: Slightly down-regulated by brassinolide.
CC       {ECO:0000269|PubMed:24299927}.
CC   -!- DISRUPTION PHENOTYPE: Dwarf phenotype with erect leaves and short
CC       grains (PubMed:24299927, PubMed:23526892). Dwarf phenotype is mainly
CC       due to decreased cell proliferation and disorganized cell files in
CC       aerial organs (PubMed:23526892). {ECO:0000269|PubMed:23526892,
CC       ECO:0000269|PubMed:24299927}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM19135.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC103891; AAM19135.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000009; ABF94807.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF11383.2; -; Genomic_DNA.
DR   EMBL; AP014959; BAS83120.1; -; Genomic_DNA.
DR   EMBL; AK068218; BAG90807.1; -; mRNA.
DR   RefSeq; XP_015632077.1; XM_015776591.1.
DR   AlphaFoldDB; Q10PI9; -.
DR   SMR; Q10PI9; -.
DR   STRING; 4530.OS03T0232600-01; -.
DR   PaxDb; Q10PI9; -.
DR   PRIDE; Q10PI9; -.
DR   EnsemblPlants; Os03t0232600-01; Os03t0232600-01; Os03g0232600.
DR   GeneID; 4332159; -.
DR   Gramene; Os03t0232600-01; Os03t0232600-01; Os03g0232600.
DR   KEGG; osa:4332159; -.
DR   eggNOG; ENOG502QTEJ; Eukaryota.
DR   HOGENOM; CLU_006348_1_2_1; -.
DR   InParanoid; Q10PI9; -.
DR   OMA; THQSVTK; -.
DR   OrthoDB; 649059at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
DR   GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
DR   GO; GO:1900457; P:regulation of brassinosteroid mediated signaling pathway; IMP:UniProtKB.
DR   CDD; cd16664; RING-Ubox_PUB; 1.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045185; PUB22/23/24-like.
DR   InterPro; IPR045210; RING-Ubox_PUB.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22849; PTHR22849; 1.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS51698; U_BOX; 1.
PE   1: Evidence at protein level;
KW   Brassinosteroid signaling pathway; Cell membrane; Membrane;
KW   Reference proteome; Repeat; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..459
FT                   /note="U-box domain-containing protein 75"
FT                   /id="PRO_0000439018"
FT   DOMAIN          64..138
FT                   /note="U-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01034"
FT   REPEAT          188..229
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          231..270
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   459 AA;  48858 MW;  31C1FA98C7F4BFC9 CRC64;
     MPQYQELPCG GQVLDIDTAL KDGILGGGPE LGDAAAGDGG KQPVELRKMM DELDAAGDGG
     GDEAVPAVFI CPISLEPMVD PVTLCTGQTY ESANISRWLA LGHRTCPTTM QELWDVTPIP
     NTTLRQLIAA WFSRRYTRFK KRSADFHGRA AELVHALRGT AVPKRQPLKG QARVAALREL
     RSLAAAHQSV TKAIAEAGGV GLLTSLLGPF TSHAVGSEAV AILVSGVPLD ADAKAALMQP
     AKVSLLVDML NEGAVDTKIN CVRLIRILME EKGFRPDTVA SLSLLVGVMR LVRDKRHPDG
     VAAGLELLNS ICAVHKPARS LIVSIGAVPQ LVELLPELPT ECVEPALDIL DALAAVPEGR
     IALKDCPRTI TNAVRLLMRV SEACTRRALS MLWVVCRMAP EECAPAALDA GLGAKLLLVI
     QSGCGPELKQ QASELLKLCT MNCTSTVFIS KCKLTKTIQ
 
 
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