ID   PUF12_CAEEL             Reviewed;         766 AA.
AC   Q09622;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Pumilio domain-containing protein 12;
GN   Name=puf-12; ORFNames=ZK945.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z48544; CAA88437.1; -; Genomic_DNA.
DR   PIR; T28120; T28120.
DR   RefSeq; NP_496178.1; NM_063777.5.
DR   AlphaFoldDB; Q09622; -.
DR   SMR; Q09622; -.
DR   BioGRID; 39891; 10.
DR   STRING; 6239.ZK945.3; -.
DR   EPD; Q09622; -.
DR   PaxDb; Q09622; -.
DR   PeptideAtlas; Q09622; -.
DR   EnsemblMetazoa; ZK945.3.1; ZK945.3.1; WBGene00014165.
DR   GeneID; 174572; -.
DR   KEGG; cel:CELE_ZK945.3; -.
DR   CTD; 174572; -.
DR   WormBase; ZK945.3; CE01734; WBGene00014165; puf-12.
DR   eggNOG; KOG2050; Eukaryota.
DR   GeneTree; ENSGT00390000015757; -.
DR   HOGENOM; CLU_013994_0_1_1; -.
DR   InParanoid; Q09622; -.
DR   OMA; WEKIRMG; -.
DR   OrthoDB; 845051at2759; -.
DR   PhylomeDB; Q09622; -.
DR   PRO; PR:Q09622; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00014165; Expressed in larva and 4 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012959; CPL_dom.
DR   InterPro; IPR033133; PUM-HD.
DR   InterPro; IPR040059; PUM3.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   PANTHER; PTHR13389; PTHR13389; 1.
DR   Pfam; PF08144; CPL; 1.
DR   SMART; SM00025; Pumilio; 4.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50302; PUM; 4.
DR   PROSITE; PS50303; PUM_HD; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..766
FT                   /note="Pumilio domain-containing protein 12"
FT                   /id="PRO_0000075934"
FT   DOMAIN          245..602
FT                   /note="PUM-HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00318"
FT   REPEAT          313..348
FT                   /note="Pumilio 1"
FT   REPEAT          461..496
FT                   /note="Pumilio 2"
FT   REPEAT          497..534
FT                   /note="Pumilio 3"
FT   REPEAT          535..571
FT                   /note="Pumilio 4"
FT   REGION          63..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   766 AA;  86955 MW;  1E00CF45F4D31226 CRC64;
     MVKLDDKNKK FKGKKKVKNV LEKKAKGLKL NKVDRKRIVK IEEKAALKSK VDKAVKDELE
     RLKKSSSTSV FDNDGTRDSL CSESSFGSQP APKKKSKKVL FSGELEHVKV FDKRVQDLQI
     KPSEASPGRG ILRSPLDKKV KKLAKVKTVK VAQEEEEEHS APPKKKVKVN AEKAVASEPA
     DDENLESVDE QAGGDESHID IPTLKRKRVA IQVTKSVKEQ LLNMPRKERK AFLKELKLKR
     KPEGARAQKC KELWEKIRMG KTPKAEKDTA VHELYGLVKG HAAKLIYAHD TSRVIECLVA
     TEREGIINNL FNELTPEIVR MSKNVYSKFF VKKMLKNGTK EQRDIIINAF RGHAPTLLRI
     KHAAEVLEYA YNDFANAHQR YNIITEFYGK EFILFREDNI RSLTEILAEK PEKKVVILKH
     LDEVIGAVNE KETLRLSILH KLMLDFFDNC DEEKKINLLD SLKDKIPEFI HTPDGAKLAI
     KLIWFAPVKE RKLIVKNFKD LSVKAAMEHY GHRVLLALFD TVDDTVLLNK VIVSELANEM
     KKLIEDDWGE KVIHYLVHPR DGRGIDKREI TFLAEGDSNP HSKKTQKDRY GQLYAGITEN
     LYPYLAANFE ELVFEANKSK FVAACLETTS SFDLFDRQVP AEARKSCNQA IVELAKKDFV
     PMDQEGFHII EHQSGNFILM AVMRCDAALQ EDERLSVALA EGLTSKQLGS WVTCNRGCHV
     LLKMLQVGGP KVIEKLKASI SRKHLDGYNS KGANLLKAQL DGNVKK