ATP6_AEDAE
ID ATP6_AEDAE Reviewed; 226 AA.
AC Q1HRS5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=ATP synthase subunit a;
DE AltName: Full=F-ATPase protein 6;
GN Name=mt:ATPase6 {ECO:0000250|UniProtKB:P00850};
GN Synonyms=ATP6 {ECO:0000312|EMBL:ABY51627.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OG Mitochondrion {ECO:0000312|EMBL:ABF18052.1}.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:ABF18052.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Black-eyed Liverpool; TISSUE=Salivary gland;
RX PubMed=17204158; DOI=10.1186/1471-2164-8-6;
RA Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K.,
RA Wikel S.K.;
RT "An annotated catalogue of salivary gland transcripts in the adult female
RT mosquito, Aedes aegypti.";
RL BMC Genomics 8:6-6(2007).
RN [2] {ECO:0000312|EMBL:ABY51627.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12 {ECO:0000312|EMBL:ABY51627.1};
RA Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V.,
RA Severson D.W.;
RT "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Key component of the
CC proton channel; it may play a direct role in the translocation of
CC protons across the membrane.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC subunits: a, b and c. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000255}.
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DR EMBL; DQ440019; ABF18052.1; -; mRNA.
DR EMBL; EU352212; ABY51627.1; -; Genomic_DNA.
DR RefSeq; YP_001649166.1; NC_010241.1.
DR AlphaFoldDB; Q1HRS5; -.
DR SMR; Q1HRS5; -.
DR STRING; 7159.AAEL018668-PA; -.
DR VEuPathDB; VectorBase:AAEL018668; -.
DR eggNOG; KOG4665; Eukaryota.
DR HOGENOM; CLU_041018_0_2_1; -.
DR InParanoid; Q1HRS5; -.
DR OrthoDB; 1095315at2759; -.
DR Proteomes; UP000008820; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR Gene3D; 1.20.120.220; -; 1.
DR InterPro; IPR000568; ATP_synth_F0_asu.
DR InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR InterPro; IPR035908; F0_ATP_A_sf.
DR PANTHER; PTHR11410; PTHR11410; 1.
DR Pfam; PF00119; ATP-synt_A; 1.
DR PRINTS; PR00123; ATPASEA.
DR SUPFAM; SSF81336; SSF81336; 1.
DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR PROSITE; PS00449; ATPASE_A; 1.
PE 2: Evidence at transcript level;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..226
FT /note="ATP synthase subunit a"
FT /id="PRO_0000347266"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 226 AA; 25323 MW; F674C37C4A534D6A CRC64;
MMTNLFSVFD PSTTILNLSL NWLSTFLGLL IIPSTYWLMP NRFQIIWNNI LLTLHKEFKT
LLGPNGHNGS TLMFVSLFSL IMFNNFLGLF PYIFTSTSHL TLTLTLAFPL WLSFMLYGWI
CHTQHMFAHL VPQGTPPVLM PFMVCIETIS NVIRPGTLAV RLTANMIAGH LLMTLLGNTG
PMSTSYIILS LILITQIALL VLESAVAIIQ SYVFAVLSTL YSSEVN