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PUG1_YEAST
ID   PUG1_YEAST              Reviewed;         303 AA.
AC   P40100; D3DM94;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Protoporphyrin uptake protein 1;
GN   Name=PUG1; OrderedLocusNames=YER185W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   PROBABLE TOPOLOGY.
RX   PubMed=12524434; DOI=10.1074/jbc.m300163200;
RA   Kim H., Melen K., von Heijne G.;
RT   "Topology models for 37 Saccharomyces cerevisiae membrane proteins based on
RT   C-terminal reporter fusions and predictions.";
RL   J. Biol. Chem. 278:10208-10213(2003).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=18326586; DOI=10.1128/ec.00414-07;
RA   Protchenko O., Shakoury-Elizeh M., Keane P., Storey J., Androphy R.,
RA   Philpott C.C.;
RT   "Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces
RT   cerevisiae.";
RL   Eukaryot. Cell 7:859-871(2008).
RN   [5]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS].
RX   PubMed=19756047; DOI=10.1038/msb.2009.64;
RA   Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.;
RT   "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals
RT   new roles for protein glycosylation in eukaryotes.";
RL   Mol. Syst. Biol. 5:308-308(2009).
CC   -!- FUNCTION: Involved in inducible protoporphyrin IX influx and heme
CC       efflux. {ECO:0000269|PubMed:18326586}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: By oxygen and heme deficiency.
CC       {ECO:0000269|PubMed:18326586}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:19756047}.
CC   -!- SIMILARITY: Belongs to the lipid-translocating exporter (LTE) (TC
CC       9.A.26.1) family. {ECO:0000305}.
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DR   EMBL; U18922; AAB64712.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07848.1; -; Genomic_DNA.
DR   PIR; S50688; S50688.
DR   RefSeq; NP_011112.3; NM_001179075.3.
DR   AlphaFoldDB; P40100; -.
DR   BioGRID; 36939; 43.
DR   IntAct; P40100; 1.
DR   STRING; 4932.YER185W; -.
DR   TCDB; 9.A.26.1.3; the lipid-translocating exporter (lte) family.
DR   iPTMnet; P40100; -.
DR   PaxDb; P40100; -.
DR   EnsemblFungi; YER185W_mRNA; YER185W; YER185W.
DR   GeneID; 856934; -.
DR   KEGG; sce:YER185W; -.
DR   SGD; S000000987; PUG1.
DR   VEuPathDB; FungiDB:YER185W; -.
DR   eggNOG; ENOG502QURG; Eukaryota.
DR   GeneTree; ENSGT00940000176387; -.
DR   HOGENOM; CLU_033465_3_1_1; -.
DR   InParanoid; P40100; -.
DR   OMA; WFMIPFA; -.
DR   BioCyc; YEAST:G3O-30341-MON; -.
DR   PRO; PR:P40100; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P40100; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR   GO; GO:0035351; P:heme transmembrane transport; IMP:SGD.
DR   InterPro; IPR007568; RTA1.
DR   PANTHER; PTHR31465; PTHR31465; 1.
DR   Pfam; PF04479; RTA1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..303
FT                   /note="Protoporphyrin uptake protein 1"
FT                   /id="PRO_0000202661"
FT   TOPO_DOM        1..18
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..76
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..303
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   303 AA;  33733 MW;  0E348C4A7CE0A772 CRC64;
     MSTTDSGFVL YHYTPSKAAA IVFVVLFIIM TVIFAVQTLY AARKSSKALK NNPFESSDDK
     VDSLEDAEYK QLKITPTVFA FIPFFTGCIM EAVGYIGRAL SSSNPERTTP YIIQSVLLLV
     APALIAATIY MIFGRLLHVM RCQSLILISA RFGTTFFVVG DVFSFFLQAA GGGLMSKAGS
     TKTGSGLITA GLFVQVIFFG FFIINEIRFT VNVKRRCLFY EDISRKWIFV NATLLLSSML
     ILLRSIVRIV EFIQGFNGYI ISHEYFIYVF DAVPMLLVII AFSVGSFFGN VFDVIKECQT
     LSN
 
 
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