PUM11_ARATH
ID PUM11_ARATH Reviewed; 556 AA.
AC Q9LDW3;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Pumilio homolog 11;
DE Short=APUM-11;
DE Short=AtPUM11;
GN Name=APUM11; OrderedLocusNames=At4g08840; ORFNames=T32A17.150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=19682068; DOI=10.1111/j.1742-4658.2009.07230.x;
RA Francischini C.W., Quaggio R.B.;
RT "Molecular characterization of Arabidopsis thaliana PUF proteins -- binding
RT specificity and target candidates.";
RL FEBS J. 276:5456-5470(2009).
RN [4]
RP GENE FAMILY.
RX PubMed=20214804; DOI=10.1186/1471-2229-10-44;
RA Tam P.P., Barrette-Ng I.H., Simon D.M., Tam M.W., Ang A.L., Muench D.G.;
RT "The Puf family of RNA-binding proteins in plants: phylogeny, structural
RT modeling, activity and subcellular localization.";
RL BMC Plant Biol. 10:44-44(2010).
CC -!- FUNCTION: Sequence-specific RNA-binding protein that regulates
CC translation and mRNA stability by binding the 3'-UTR of target mRNAs.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: The pumilio repeats mediate the association with RNA by packing
CC together to form a right-handed superhelix that approximates a half
CC donut. The number as well as the specific sequence of the repeats
CC determine the specificity for target mRNAs (By similarity).
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB78009.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB82120.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL161513; CAB78009.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161813; CAB82120.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82681.1; -; Genomic_DNA.
DR PIR; A85089; A85089.
DR RefSeq; NP_192624.2; NM_116954.2.
DR AlphaFoldDB; Q9LDW3; -.
DR SMR; Q9LDW3; -.
DR STRING; 3702.AT4G08840.1; -.
DR PaxDb; Q9LDW3; -.
DR PRIDE; Q9LDW3; -.
DR EnsemblPlants; AT4G08840.1; AT4G08840.1; AT4G08840.
DR GeneID; 826455; -.
DR Gramene; AT4G08840.1; AT4G08840.1; AT4G08840.
DR KEGG; ath:AT4G08840; -.
DR Araport; AT4G08840; -.
DR TAIR; locus:2138258; AT4G08840.
DR eggNOG; KOG2049; Eukaryota.
DR HOGENOM; CLU_004017_5_2_1; -.
DR InParanoid; Q9LDW3; -.
DR OMA; TCASARF; -.
DR OrthoDB; 1364009at2759; -.
DR PhylomeDB; Q9LDW3; -.
DR PRO; PR:Q9LDW3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9LDW3; baseline and differential.
DR Genevisible; Q9LDW3; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd07920; Pumilio; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR033712; Pumilio_RNA-bd.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR Pfam; PF00806; PUF; 8.
DR SMART; SM00025; Pumilio; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50302; PUM; 7.
DR PROSITE; PS50303; PUM_HD; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; RNA-binding; Translation regulation.
FT CHAIN 1..556
FT /note="Pumilio homolog 11"
FT /id="PRO_0000401393"
FT DOMAIN 215..556
FT /note="PUM-HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00318"
FT REPEAT 238..276
FT /note="Pumilio 1"
FT REPEAT 277..313
FT /note="Pumilio 2"
FT REPEAT 316..351
FT /note="Pumilio 3"
FT REPEAT 353..388
FT /note="Pumilio 4"
FT REPEAT 389..424
FT /note="Pumilio 5"
FT REPEAT 425..459
FT /note="Pumilio 6"
FT REPEAT 460..495
FT /note="Pumilio 7"
FT REPEAT 496..531
FT /note="Pumilio 8"
SQ SEQUENCE 556 AA; 63129 MW; 2AEA5EEE3C6A046E CRC64;
MDFGFFPGDL RQRGSFTDLG FNGFPLTSSV SNGFHFSGDR TTNPFLNLRK LDTTSLMADG
VDMGLCQNLS KMSISDERSN FFNHSSFSGY GCYQGRESSF HGEASSSMRG FVGYGDVHRF
EQDLRVRASF HGESAMSSYV GDGSDYHRLR FLALQEASNP NPRCFTENMS LLNRDYMLEL
EHFNQQIRRD FSLVPQKSPL AFHEERILPP FSAMGGSREL DGSAKCMKNK EDSLDLASMV
DSYGSVYLMA KDQLGCRLLQ KFVDEGNFVD VMIIFKEVIN NVIELGTDPF GNYLIQKLIE
VCNEEQRTQI LIRLTSKPGL LVKISINNYG TRVVQKLIET VTTKEQISLV KSALVPGFLS
LFRELNGNHV ILNCLKFFSP NDNKFILEAA TKFCIEIATT RHGCCVLQRC VSYSVGEQHE
KLVDEISRNS LLLAQDPFGN YLVQYIIEKK VGGVNVLFEL RGNYVKLATQ KFGSHVVEKC
LRYYPESRSQ IVNELVSVLN FGYLLQDPYA NYVIQCALSK TKGFVRASLV EKVRRYENLK
MTPYCKRIFS KNLWKK
