PUM17_ARATH
ID PUM17_ARATH Reviewed; 332 AA.
AC Q9C8B8; F4I006;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Putative pumilio homolog 17;
DE Short=APUM-17;
DE Short=AtPUM17;
GN Name=APUM17; OrderedLocusNames=At1g35850; ORFNames=F10O5.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=19682068; DOI=10.1111/j.1742-4658.2009.07230.x;
RA Francischini C.W., Quaggio R.B.;
RT "Molecular characterization of Arabidopsis thaliana PUF proteins -- binding
RT specificity and target candidates.";
RL FEBS J. 276:5456-5470(2009).
RN [4]
RP GENE FAMILY.
RX PubMed=20214804; DOI=10.1186/1471-2229-10-44;
RA Tam P.P., Barrette-Ng I.H., Simon D.M., Tam M.W., Ang A.L., Muench D.G.;
RT "The Puf family of RNA-binding proteins in plants: phylogeny, structural
RT modeling, activity and subcellular localization.";
RL BMC Plant Biol. 10:44-44(2010).
CC -!- FUNCTION: Sequence-specific RNA-binding protein that regulates
CC translation and mRNA stability by binding the 3'-UTR of target mRNAs.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: The pumilio repeats mediate the association with RNA by packing
CC together to form a right-handed superhelix that approximates a half
CC donut. The number as well as the specific sequence of the repeats
CC determine the specificity for target mRNAs (By similarity).
CC {ECO:0000250}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51092.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51092.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AEE31831.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC027032; AAG51092.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31831.1; ALT_SEQ; Genomic_DNA.
DR PIR; D86480; D86480.
DR RefSeq; NP_174820.1; NM_103284.1.
DR AlphaFoldDB; Q9C8B8; -.
DR SMR; Q9C8B8; -.
DR STRING; 3702.AT1G35850.1; -.
DR PRIDE; Q9C8B8; -.
DR GeneID; 840487; -.
DR KEGG; ath:AT1G35850; -.
DR Araport; AT1G35850; -.
DR eggNOG; KOG2049; Eukaryota.
DR InParanoid; Q9C8B8; -.
DR OrthoDB; 1191728at2759; -.
DR PhylomeDB; Q9C8B8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR Pfam; PF00806; PUF; 3.
DR SMART; SM00025; Pumilio; 5.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50302; PUM; 5.
DR PROSITE; PS50303; PUM_HD; 1.
PE 5: Uncertain;
KW Cytoplasm; Reference proteome; Repeat; RNA-binding; Translation regulation.
FT CHAIN 1..332
FT /note="Putative pumilio homolog 17"
FT /id="PRO_0000401399"
FT DOMAIN 1..302
FT /note="PUM-HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00318"
FT REPEAT 82..117
FT /note="Pumilio 1"
FT REPEAT 118..152
FT /note="Pumilio 2; degenerate"
FT REPEAT 153..188
FT /note="Pumilio 3"
FT REPEAT 189..225
FT /note="Pumilio 4"
FT REPEAT 226..264
FT /note="Pumilio 5"
FT REPEAT 265..300
FT /note="Pumilio 6"
SQ SEQUENCE 332 AA; 38511 MW; 833DB64FFC3A9DB9 CRC64;
MTNINRLSMS TMFNALHEIL NEEPLAIPPP PSRGGYSYFH IRTTEMDLQR MFNFMTGSED
LKDDISVLDT GMLMWMASFL TSDSDYFMVI TRNKNGSKSL QKLMRMSDDM DVFFFVAIMR
LFIHVMIDKY ASYVAIQGMR IFKQDKRELM YDHILRYALF LARDQYGCIA LNEIIKELDD
PYYRDELMDI VSNNALLLSN DAYGNFVVQH VLKLHDSRCT GNIADKLCGY CVELSFKKYG
SYIVERLLEV RDIPMATIVL DLLACKTEML IRLARSENGN FVVCKLLELT NDILTADLFY
SLVNKLRPYR FLLHRFPESK IVAILGSMRV PN
