PUP11_ARATH
ID PUP11_ARATH Reviewed; 379 AA.
AC Q9LPF6; Q2V4I7; Q3E7M0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Probable purine permease 11;
DE Short=AtPUP11;
GN Name=PUP11; OrderedLocusNames=At1g44750; ORFNames=T12C22.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INTERACTION WITH KAT1.
RX PubMed=15299147; DOI=10.1073/pnas.0404467101;
RA Obrdlik P., El-Bakkoury M., Hamacher T., Cappellaro C., Vilarino C.,
RA Fleischer C., Ellerbrok H., Kamuzinzi R., Ledent V., Blaudez D.,
RA Sanders D., Revuelta J.L., Boles E., Andre B., Frommer W.B.;
RT "K+ channel interactions detected by a genetic system optimized for
RT systematic studies of membrane protein interactions.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12242-12247(2004).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=10662864; DOI=10.2307/3870929;
RA Gillissen B., Buerkle L., Andre B., Kuehn C., Rentsch D., Brandl B.,
RA Frommer W.B.;
RT "A new family of high-affinity transporters for adenine, cytosine, and
RT purine derivatives in Arabidopsis.";
RL Plant Cell 12:291-300(2000).
CC -!- SUBUNIT: May form a complex with the potassium channel subunit KAT1.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9LPF6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LPF6-2; Sequence=VSP_030946;
CC Name=3;
CC IsoId=Q9LPF6-3; Sequence=VSP_030945;
CC -!- SIMILARITY: Belongs to the purine permeases (TC 2.A.7.14) family.
CC {ECO:0000305}.
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DR EMBL; AC020576; AAF78258.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32044.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32045.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32046.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60502.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60503.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60504.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60505.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60506.1; -; Genomic_DNA.
DR EMBL; AY062782; AAL32860.1; -; mRNA.
DR EMBL; BT003358; AAO29976.1; -; mRNA.
DR PIR; D96506; D96506.
DR RefSeq; NP_001031147.1; NM_001036070.1. [Q9LPF6-3]
DR RefSeq; NP_001319164.1; NM_001333232.1. [Q9LPF6-3]
DR RefSeq; NP_001322784.1; NM_001333233.1. [Q9LPF6-3]
DR RefSeq; NP_001322785.1; NM_001333234.1. [Q9LPF6-3]
DR RefSeq; NP_001322786.1; NM_001333235.1. [Q9LPF6-2]
DR RefSeq; NP_001322787.1; NM_001333236.1. [Q9LPF6-3]
DR RefSeq; NP_175096.1; NM_103556.4. [Q9LPF6-1]
DR RefSeq; NP_973972.1; NM_202243.3. [Q9LPF6-2]
DR AlphaFoldDB; Q9LPF6; -.
DR BioGRID; 26264; 1.
DR IntAct; Q9LPF6; 1.
DR STRING; 3702.AT1G44750.1; -.
DR TCDB; 2.A.7.14.3; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; Q9LPF6; -.
DR PRIDE; Q9LPF6; -.
DR ProteomicsDB; 224867; -. [Q9LPF6-1]
DR EnsemblPlants; AT1G44750.1; AT1G44750.1; AT1G44750. [Q9LPF6-1]
DR EnsemblPlants; AT1G44750.2; AT1G44750.2; AT1G44750. [Q9LPF6-2]
DR EnsemblPlants; AT1G44750.3; AT1G44750.3; AT1G44750. [Q9LPF6-3]
DR EnsemblPlants; AT1G44750.4; AT1G44750.4; AT1G44750. [Q9LPF6-3]
DR EnsemblPlants; AT1G44750.5; AT1G44750.5; AT1G44750. [Q9LPF6-3]
DR EnsemblPlants; AT1G44750.6; AT1G44750.6; AT1G44750. [Q9LPF6-2]
DR EnsemblPlants; AT1G44750.7; AT1G44750.7; AT1G44750. [Q9LPF6-3]
DR EnsemblPlants; AT1G44750.8; AT1G44750.8; AT1G44750. [Q9LPF6-3]
DR GeneID; 841039; -.
DR Gramene; AT1G44750.1; AT1G44750.1; AT1G44750. [Q9LPF6-1]
DR Gramene; AT1G44750.2; AT1G44750.2; AT1G44750. [Q9LPF6-2]
DR Gramene; AT1G44750.3; AT1G44750.3; AT1G44750. [Q9LPF6-3]
DR Gramene; AT1G44750.4; AT1G44750.4; AT1G44750. [Q9LPF6-3]
DR Gramene; AT1G44750.5; AT1G44750.5; AT1G44750. [Q9LPF6-3]
DR Gramene; AT1G44750.6; AT1G44750.6; AT1G44750. [Q9LPF6-2]
DR Gramene; AT1G44750.7; AT1G44750.7; AT1G44750. [Q9LPF6-3]
DR Gramene; AT1G44750.8; AT1G44750.8; AT1G44750. [Q9LPF6-3]
DR KEGG; ath:AT1G44750; -.
DR Araport; AT1G44750; -.
DR TAIR; locus:2194814; AT1G44750.
DR eggNOG; ENOG502QRUH; Eukaryota.
DR InParanoid; Q9LPF6; -.
DR OMA; ASGEWMT; -.
DR OrthoDB; 953055at2759; -.
DR PhylomeDB; Q9LPF6; -.
DR PRO; PR:Q9LPF6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LPF6; baseline and differential.
DR Genevisible; Q9LPF6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; TAS:TAIR.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; TAS:TAIR.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006863; P:purine nucleobase transport; TAS:TAIR.
DR InterPro; IPR030182; PUP_plant.
DR PANTHER; PTHR31376; PTHR31376; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..379
FT /note="Probable purine permease 11"
FT /id="PRO_0000317398"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..76
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_030945"
FT VAR_SEQ 1..14
FT /note="MAKEPVRVLVTGAA -> MS (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_030946"
SQ SEQUENCE 379 AA; 41290 MW; F1ED85A70FAD7001 CRC64;
MAKEPVRVLV TGAAGNQEPI LVKEESVVGI PTPLLKLKSW QWWVLVSVNI FFLIGGQAAS
VLLGRFYYDE GGNSKWMATL VQTAAFPILY IPLLLLPSSA SVESSESSCS LKYIVLIYVL
LGVIIAGDNM LYSVGLLYLS ASTYSLICAT QLAFNAVFSY FINAQKFTAL ILNSVVLLSF
SAALIALNDD ADTPSGVSRS KYIVGFVCTL AASALYSLLL SLMQFSFEKI LKRETFSVVL
EMQIYTSLVA TCVSVIGLFA SGEWRTLHGE MEGYHKGQAS YVLTLVWTAV TWQVCSVGVV
GLIFLVTSLF SNVISTLSLA VTPLAALVVF RDKMSGVKIM AMLIAIWGFA SYVYQNHIDD
LKVRQARQQA QAGRVEPPC
