ID   PUP12_ARATH             Reviewed;         358 AA.
AC   Q9FLL4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Putative purine permease 12;
DE            Short=AtPUP12;
GN   Name=PUP12; Synonyms=PUP10; OrderedLocusNames=At5g41160; ORFNames=MEE6.23;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA   Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT   features of the regions of 1,456,315 bp covered by nineteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:41-54(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=10662864; DOI=10.2307/3870929;
RA   Gillissen B., Buerkle L., Andre B., Kuehn C., Rentsch D., Brandl B.,
RA   Frommer W.B.;
RT   "A new family of high-affinity transporters for adenine, cytosine, and
RT   purine derivatives in Arabidopsis.";
RL   Plant Cell 12:291-300(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the purine permeases (TC 2.A.7.14) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB010072; BAB09718.1; -; Genomic_DNA.
DR   EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q9FLL4; -.
DR   SMR; Q9FLL4; -.
DR   IntAct; Q9FLL4; 1.
DR   STRING; 3702.AT5G41160.1; -.
DR   PaxDb; Q9FLL4; -.
DR   PRIDE; Q9FLL4; -.
DR   ProteomicsDB; 226362; -.
DR   EnsemblPlants; AT5G41160.1; AT5G41160.1; AT5G41160.
DR   Gramene; AT5G41160.1; AT5G41160.1; AT5G41160.
DR   Araport; AT5G41160; -.
DR   TAIR; locus:2163026; AT5G41160.
DR   eggNOG; ENOG502QRUH; Eukaryota.
DR   HOGENOM; CLU_043459_2_1_1; -.
DR   InParanoid; Q9FLL4; -.
DR   PhylomeDB; Q9FLL4; -.
DR   PRO; PR:Q9FLL4; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FLL4; baseline and differential.
DR   Genevisible; Q9FLL4; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; TAS:TAIR.
DR   GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; TAS:TAIR.
DR   GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006863; P:purine nucleobase transport; TAS:TAIR.
DR   InterPro; IPR030182; PUP_plant.
DR   PANTHER; PTHR31376; PTHR31376; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..358
FT                   /note="Putative purine permease 12"
FT                   /id="PRO_0000317399"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   358 AA;  39623 MW;  7B4F714639D721D9 CRC64;
     MLLLKEEDEG RRRTSVPTQL MKLNRSQWWI LVFISIFFLI SAQAISVLLG RFYYNEGGNS
     KWISTLVQTG GFPILYLPLS LLPASQSSSS SSSSSSFKTL VWIYLSLGFA IGLDNFLYSV
     GLLYLSASTY SILCASQLAF NGVFYYYINS QKITCLIFFS VLFLSISAVL VSLDDDSNSP
     SGDSKWSYLI GCFCAVFASL IYSLQLSLMQ FSFEKVLKSE TLSMVLEMQI YTSLVASCVA
     VIGLFASGEW MLLSVEMEEF QEGQVIYVLT LVGAAVSCQL GCVGAVSLIF LVSSLFSNLI
     STLSLIVTPL AAIAVFHDKL TEVKMVAMPI AFTGFTFYIY QNYLDDLKVQ RAREAQAE