PUP16_ARATH
ID PUP16_ARATH Reviewed; 383 AA.
AC O04508;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable purine permease 16;
DE Short=AtPUP16;
GN Name=PUP16; OrderedLocusNames=At1g09860; ORFNames=F21M12.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=10662864; DOI=10.2307/3870929;
RA Gillissen B., Buerkle L., Andre B., Kuehn C., Rentsch D., Brandl B.,
RA Frommer W.B.;
RT "A new family of high-affinity transporters for adenine, cytosine, and
RT purine derivatives in Arabidopsis.";
RL Plant Cell 12:291-300(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the purine permeases (TC 2.A.7.14) family.
CC {ECO:0000305}.
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DR EMBL; AC000132; AAB60739.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28508.1; -; Genomic_DNA.
DR EMBL; BX815869; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; H86232; H86232.
DR RefSeq; NP_172457.1; NM_100860.3.
DR AlphaFoldDB; O04508; -.
DR BioGRID; 22759; 2.
DR IntAct; O04508; 1.
DR STRING; 3702.AT1G09860.1; -.
DR PaxDb; O04508; -.
DR PRIDE; O04508; -.
DR EnsemblPlants; AT1G09860.1; AT1G09860.1; AT1G09860.
DR GeneID; 837518; -.
DR Gramene; AT1G09860.1; AT1G09860.1; AT1G09860.
DR KEGG; ath:AT1G09860; -.
DR Araport; AT1G09860; -.
DR TAIR; locus:2024382; AT1G09860.
DR HOGENOM; CLU_043459_2_1_1; -.
DR InParanoid; O04508; -.
DR OMA; YVQDNRS; -.
DR OrthoDB; 997088at2759; -.
DR PhylomeDB; O04508; -.
DR PRO; PR:O04508; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04508; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; TAS:TAIR.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; TAS:TAIR.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006863; P:purine nucleobase transport; TAS:TAIR.
DR InterPro; IPR030182; PUP_plant.
DR PANTHER; PTHR31376; PTHR31376; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..383
FT /note="Probable purine permease 16"
FT /id="PRO_0000317403"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 179
FT /note="F -> L (in Ref. 3; BX815869)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 383 AA; 43225 MW; 388529C91556162E CRC64;
MEEFQGPEPR GQMMSENPRS LELNQRKWWI SVFICGFLIF AGDSLVMLLL NFFYVQDNRS
ESDQDRQYKG TWTQALIQNA AFPILIPFFF ILSSPKPNPE TVSNQTNNGW FRVLSLYVSL
GVLVSVYSKL YALGKLYVGW GILLSTQLIL TSLFSAFINR LKFNRWIIIS IIFTLGADFF
GGPAFAGTPN EDETDPYDIK AWLILIFPTL AFSLSLCLMQ LGFDKVLVKT KRYGNKKVFR
MVLEMQICVS FIATLICTVG LFASGEFKEL KGDSERFKKG KTYYILSLVG LALSWQVWAV
GLLGLVLLVS GLFADVVHMG ASPVVALLVV LAFDFMDDEF GWQRRGALLG AVLALASYFY
SLHTKKKKEI AELNKRENNN SEA
