PUP17_ARATH
ID PUP17_ARATH Reviewed; 398 AA.
AC Q1PFJ4; Q9C655;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Probable purine permease 17;
DE Short=AtPUP17;
GN Name=PUP17; OrderedLocusNames=At1g57943; ORFNames=F13D13.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=10662864; DOI=10.2307/3870929;
RA Gillissen B., Buerkle L., Andre B., Kuehn C., Rentsch D., Brandl B.,
RA Frommer W.B.;
RT "A new family of high-affinity transporters for adenine, cytosine, and
RT purine derivatives in Arabidopsis.";
RL Plant Cell 12:291-300(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1PFJ4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1PFJ4-2; Sequence=VSP_030947;
CC -!- SIMILARITY: Belongs to the purine permeases (TC 2.A.7.14) family.
CC {ECO:0000305}.
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DR EMBL; AC079991; AAG50664.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33479.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33480.1; -; Genomic_DNA.
DR EMBL; DQ056499; AAY78656.1; -; mRNA.
DR EMBL; DQ446369; ABE65719.1; -; mRNA.
DR PIR; C96613; C96613.
DR RefSeq; NP_001077737.1; NM_001084268.2. [Q1PFJ4-2]
DR RefSeq; NP_176098.1; NM_104582.2. [Q1PFJ4-1]
DR AlphaFoldDB; Q1PFJ4; -.
DR BioGRID; 27389; 7.
DR IntAct; Q1PFJ4; 7.
DR PaxDb; Q1PFJ4; -.
DR PRIDE; Q1PFJ4; -.
DR EnsemblPlants; AT1G57943.1; AT1G57943.1; AT1G57943. [Q1PFJ4-1]
DR EnsemblPlants; AT1G57943.2; AT1G57943.2; AT1G57943. [Q1PFJ4-2]
DR GeneID; 842164; -.
DR Gramene; AT1G57943.1; AT1G57943.1; AT1G57943. [Q1PFJ4-1]
DR Gramene; AT1G57943.2; AT1G57943.2; AT1G57943. [Q1PFJ4-2]
DR KEGG; ath:AT1G57943; -.
DR Araport; AT1G57943; -.
DR TAIR; locus:2824334; AT1G57943.
DR eggNOG; ENOG502QRUH; Eukaryota.
DR HOGENOM; CLU_043459_2_1_1; -.
DR InParanoid; Q1PFJ4; -.
DR OMA; MEQDFHE; -.
DR OrthoDB; 741120at2759; -.
DR PhylomeDB; Q1PFJ4; -.
DR PRO; PR:Q1PFJ4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1PFJ4; baseline and differential.
DR Genevisible; Q1PFJ4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; TAS:TAIR.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; TAS:TAIR.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006863; P:purine nucleobase transport; TAS:TAIR.
DR InterPro; IPR030182; PUP_plant.
DR PANTHER; PTHR31376; PTHR31376; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..398
FT /note="Probable purine permease 17"
FT /id="PRO_0000317404"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C508"
FT VAR_SEQ 14
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17147637"
FT /id="VSP_030947"
SQ SEQUENCE 398 AA; 45393 MW; D06273D31A817DAC CRC64;
MEMSKASKQT TRHEESEHVQ NPEPDQILSP RRSLELKQRK WWISVSLCLF LVLLGDSLVM
LLLNFFYVQM KQDRREEYDQ DLQYKGTWTQ ALIQNAAFPI LIPLFFIFPK PKQHLETNNT
SFLSLRLFFL YLSLGVLVAA HSKLFALGKL VSNYGIFSLI STTQLIFTAV LTAIINRFKF
TRWIIISILL TIVIYVLGTP DFGGQPHDGE EFGYNIQAWL AFSATIAFSL SLCLIQLGFE
KLQVKTKRYG NEKVFRMVLE MQICVAFVAS VVCLVGLFAS DEYKELKGDS KRFKKGETYY
VLSLVGLALS WQVWAVGMIG LVHYVSGLFG DVVHMCASPF VALFVVLAFD FMDDVFSWPR
IGALIGTVLA LGSYFYTLHK RNKKKMAELN QSENNVEV
