PUP4_ARATH
ID PUP4_ARATH Reviewed; 382 AA.
AC Q9SY29;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Probable purine permease 4;
DE Short=AtPUP4;
GN Name=PUP4; OrderedLocusNames=At1g30840; ORFNames=T17H7.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=10662864; DOI=10.2307/3870929;
RA Gillissen B., Buerkle L., Andre B., Kuehn C., Rentsch D., Brandl B.,
RA Frommer W.B.;
RT "A new family of high-affinity transporters for adenine, cytosine, and
RT purine derivatives in Arabidopsis.";
RL Plant Cell 12:291-300(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the purine permeases (TC 2.A.7.14) family.
CC {ECO:0000305}.
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DR EMBL; AC004135; AAD32940.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31282.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31283.1; -; Genomic_DNA.
DR EMBL; BT004160; AAO42180.1; -; mRNA.
DR EMBL; BT005495; AAO63915.1; -; mRNA.
DR EMBL; AY084641; AAM61204.1; -; mRNA.
DR RefSeq; NP_001185119.1; NM_001198190.1.
DR RefSeq; NP_564365.1; NM_102821.3.
DR AlphaFoldDB; Q9SY29; -.
DR SMR; Q9SY29; -.
DR BioGRID; 25202; 28.
DR IntAct; Q9SY29; 26.
DR STRING; 3702.AT1G30840.1; -.
DR PaxDb; Q9SY29; -.
DR PRIDE; Q9SY29; -.
DR ProteomicsDB; 226260; -.
DR EnsemblPlants; AT1G30840.1; AT1G30840.1; AT1G30840.
DR EnsemblPlants; AT1G30840.2; AT1G30840.2; AT1G30840.
DR GeneID; 839967; -.
DR Gramene; AT1G30840.1; AT1G30840.1; AT1G30840.
DR Gramene; AT1G30840.2; AT1G30840.2; AT1G30840.
DR KEGG; ath:AT1G30840; -.
DR Araport; AT1G30840; -.
DR TAIR; locus:2196989; AT1G30840.
DR eggNOG; ENOG502QVXU; Eukaryota.
DR HOGENOM; CLU_043459_0_1_1; -.
DR InParanoid; Q9SY29; -.
DR OMA; FAHGGHN; -.
DR OrthoDB; 1198269at2759; -.
DR PhylomeDB; Q9SY29; -.
DR PRO; PR:Q9SY29; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SY29; baseline and differential.
DR Genevisible; Q9SY29; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; TAS:TAIR.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; TAS:TAIR.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006863; P:purine nucleobase transport; TAS:TAIR.
DR InterPro; IPR030182; PUP_plant.
DR PANTHER; PTHR31376; PTHR31376; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..382
FT /note="Probable purine permease 4"
FT /id="PRO_0000317391"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 66..170
FT /note="EamA"
FT REGION 345..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 42321 MW; E030A23A8C834ACA CRC64;
MSDGRVNADP QQEENMVKPP VKRSLTLLIV TYFFLFFGSI ASSLLAKYYF VYGGSSRWVS
TWVQSAGFPL LLILIYFPHY VLKTTTRRPF TRFTLRHLIF SVLIGLVLGF NNFLFSWGTS
YLPVSTSSLL LSTQLVFTLI LSRIIVKQKI TFSNLNCVVL LTLSSVLLAL DSSKDKPSGL
TKTKYFIGYV STIGAGLLFA LYLPVTEKLY RTVYCYAMVM EVQLVMEFAA TVFATIGMAC
EGGFKEMVKE ANHVFTKGPT FYWTFAILAN VVTWQLSFAA TSGMVYLTSG ITGGICMTAL
LAMNVIGGVV AYGDVFGGVK IVSTVLCIWG FSSYTYGMYM KMKKEEKEKG EYSGVKTTED
SGEMEVEMGN VKDDVAAADD RA
