ID   PUP5_ARATH              Reviewed;         361 AA.
AC   Q9ZUH3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Probable purine permease 5;
DE            Short=AtPUP5;
GN   Name=PUP5; Synonyms=PUP11; OrderedLocusNames=At2g24220; ORFNames=F27D4.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=10662864; DOI=10.2307/3870929;
RA   Gillissen B., Buerkle L., Andre B., Kuehn C., Rentsch D., Brandl B.,
RA   Frommer W.B.;
RT   "A new family of high-affinity transporters for adenine, cytosine, and
RT   purine derivatives in Arabidopsis.";
RL   Plant Cell 12:291-300(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the purine permeases (TC 2.A.7.14) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD03383.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC005967; AAD03383.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002685; AEC07544.1; -; Genomic_DNA.
DR   PIR; A84634; A84634.
DR   RefSeq; NP_179999.2; NM_127983.3.
DR   AlphaFoldDB; Q9ZUH3; -.
DR   SMR; Q9ZUH3; -.
DR   BioGRID; 2308; 11.
DR   IntAct; Q9ZUH3; 10.
DR   STRING; 3702.AT2G24220.2; -.
DR   PaxDb; Q9ZUH3; -.
DR   PRIDE; Q9ZUH3; -.
DR   EnsemblPlants; AT2G24220.1; AT2G24220.1; AT2G24220.
DR   GeneID; 816956; -.
DR   Gramene; AT2G24220.1; AT2G24220.1; AT2G24220.
DR   KEGG; ath:AT2G24220; -.
DR   Araport; AT2G24220; -.
DR   TAIR; locus:2047520; AT2G24220.
DR   eggNOG; ENOG502QT64; Eukaryota.
DR   HOGENOM; CLU_043459_1_1_1; -.
DR   InParanoid; Q9ZUH3; -.
DR   PhylomeDB; Q9ZUH3; -.
DR   PRO; PR:Q9ZUH3; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZUH3; baseline and differential.
DR   Genevisible; Q9ZUH3; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; TAS:TAIR.
DR   GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; TAS:TAIR.
DR   GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006863; P:purine nucleobase transport; TAS:TAIR.
DR   InterPro; IPR030182; PUP_plant.
DR   PANTHER; PTHR31376; PTHR31376; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..361
FT                   /note="Probable purine permease 5"
FT                   /id="PRO_0000317392"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          75..178
FT                   /note="EamA"
SQ   SEQUENCE   361 AA;  39174 MW;  547CE09F85DCCCD6 CRC64;
     MDETTERPTV SFSYSNWISN IKKSTREAYE AKPFSHWILL FFSGAAMLIA FPASSLLSRL
     YFSNGGKSKW IISWVAVAGW PITCLILLPT YIFQKIKPTP LNTKLVLSYV VLGFLSAADN
     LMYAYAYAYL PASTSSLLAS SSLAFSALFG YLIVKNPLNA SVINSIVVIT GAMAIIALDS
     SSDRYSYISN SQYFAGFFWD IMGSALHGLI FALSELLFVK LLGRRSFHVA LEQQVMVSLT
     AFAFTTIGMV VSNDFQGMSH EAKSFKGGES LYTQVLVWSA VTFQLGVLGA TAVLFLASTV
     MAGVLNAVRV PITSVAAVIL MHDPMSGFKI LSLVLTFWGF SSYIYGSSSS NSSTQASSSS
     S