1433B_CHICK
ID 1433B_CHICK Reviewed; 244 AA.
AC Q5ZLQ6;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=14-3-3 protein beta/alpha;
GN Name=YWHAB; ORFNames=RCJMB04_5d11;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Adapter protein implicated in the regulation of a large
CC spectrum of both general and specialized signaling pathways. Binds to a
CC large number of partners, usually by recognition of a phosphoserine or
CC phosphothreonine motif. Binding generally results in the modulation of
CC the activity of the binding partner (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer, and heterodimer with other family members.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
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DR EMBL; AJ719678; CAG31337.1; -; mRNA.
DR RefSeq; NP_001006289.1; NM_001006289.1.
DR AlphaFoldDB; Q5ZLQ6; -.
DR SMR; Q5ZLQ6; -.
DR BioGRID; 680338; 2.
DR IntAct; Q5ZLQ6; 1.
DR STRING; 9031.ENSGALP00000043305; -.
DR PaxDb; Q5ZLQ6; -.
DR PRIDE; Q5ZLQ6; -.
DR Ensembl; ENSGALT00000044506; ENSGALP00000043305; ENSGALG00000004143.
DR Ensembl; ENSGALT00000091201; ENSGALP00000071615; ENSGALG00000004143.
DR Ensembl; ENSGALT00000107000; ENSGALP00000066011; ENSGALG00000004143.
DR GeneID; 419190; -.
DR KEGG; gga:419190; -.
DR CTD; 7529; -.
DR VEuPathDB; HostDB:geneid_419190; -.
DR eggNOG; KOG0841; Eukaryota.
DR GeneTree; ENSGT01050000244817; -.
DR HOGENOM; CLU_058290_1_0_1; -.
DR InParanoid; Q5ZLQ6; -.
DR OMA; KGCQLAR; -.
DR OrthoDB; 1176818at2759; -.
DR PhylomeDB; Q5ZLQ6; -.
DR TreeFam; TF102003; -.
DR Reactome; R-GGA-165159; MTOR signalling.
DR Reactome; R-GGA-166208; mTORC1-mediated signalling.
DR Reactome; R-GGA-170968; Frs2-mediated activation.
DR Reactome; R-GGA-2028269; Signaling by Hippo.
DR Reactome; R-GGA-392517; Rap1 signalling.
DR Reactome; R-GGA-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR Reactome; R-GGA-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-GGA-5673000; RAF activation.
DR Reactome; R-GGA-5674135; MAP2K and MAPK activation.
DR Reactome; R-GGA-5675221; Negative regulation of MAPK pathway.
DR Reactome; R-GGA-9614399; Regulation of localization of FOXO transcription factors.
DR PRO; PR:Q5ZLQ6; -.
DR Proteomes; UP000000539; Chromosome 20.
DR Bgee; ENSGALG00000004143; Expressed in brain and 14 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0050815; F:phosphoserine residue binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0051220; P:cytoplasmic sequestering of protein; IEA:Ensembl.
DR GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035308; P:negative regulation of protein dephosphorylation; IEA:Ensembl.
DR GO; GO:0043085; P:positive regulation of catalytic activity; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0006605; P:protein targeting; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.190.20; -; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR023409; 14-3-3_CS.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR PANTHER; PTHR18860; PTHR18860; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PIRSF; PIRSF000868; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SMART; SM00101; 14_3_3; 1.
DR SUPFAM; SSF48445; SSF48445; 1.
DR PROSITE; PS00796; 1433_1; 1.
DR PROSITE; PS00797; 1433_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..244
FT /note="14-3-3 protein beta/alpha"
FT /id="PRO_0000058597"
FT SITE 56
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000250"
FT SITE 127
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 244 AA; 27907 MW; 200272F6434A5254 CRC64;
MDKSELVQKA KLAEQAERYD DMAAAMKAVT EQGHELSNEE RNLLSVAYKN VVGARRSSWR
VISSIEQKTE RNEKKQQMGR EYREKIEAEL QDICNDVLEL LDKYLIVNAT QPESKVFYLK
MKGDYYRYLS EVASGDNKQT TVANSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE
ILNSPEKACN LAKTAFDEAI AELDTLNEES YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG
EGEN
