ID   AADK_STAAU              Reviewed;         282 AA.
AC   P12055;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Aminoglycoside 6-adenylyltransferase {ECO:0000250|UniProtKB:P17585};
DE            EC=2.7.7.- {ECO:0000250|UniProtKB:P17585};
DE   AltName: Full=AAD(6) {ECO:0000250|UniProtKB:P17585};
DE   AltName: Full=Streptomycin 6-adenylyltransferase {ECO:0000250|UniProtKB:P17585};
GN   Name=str {ECO:0000303|PubMed:3357770}; Synonyms=aadK {ECO:0000305};
OS   Staphylococcus aureus.
OG   Plasmid pS194.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3357770; DOI=10.1093/nar/16.5.2179;
RA   Projan S.J., Moghazeh S., Novick R.P.;
RT   "Nucleotide sequence of pS194, a streptomycin-resistance plasmid from
RT   Staphylococcus aureus.";
RL   Nucleic Acids Res. 16:2179-2187(1988).
CC   -!- FUNCTION: Required for streptomycin resistance (PubMed:3357770).
CC       Adenylates streptomycin on the O-6 residue (By similarity).
CC       {ECO:0000250|UniProtKB:P17585, ECO:0000269|PubMed:3357770}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:63236, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:146262;
CC         Evidence={ECO:0000250|UniProtKB:P17585};
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DR   EMBL; X06627; CAA29839.1; -; Genomic_DNA.
DR   PIR; S00938; S00938.
DR   RefSeq; NP_976271.1; NC_005564.1.
DR   RefSeq; WP_001258486.1; NZ_WNWJ01000020.1.
DR   AlphaFoldDB; P12055; -.
DR   SMR; P12055; -.
DR   GeneID; 61682024; -.
DR   PRO; PR:P12055; -.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR007530; Aminoglycoside_adenylylTfrase.
DR   InterPro; IPR043519; NT_sf.
DR   Pfam; PF04439; Adenyl_transf; 1.
DR   PIRSF; PIRSF000812; AAD; 1.
DR   SUPFAM; SSF81301; SSF81301; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Plasmid; Transferase.
FT   CHAIN           1..282
FT                   /note="Aminoglycoside 6-adenylyltransferase"
FT                   /id="PRO_0000068589"
SQ   SEQUENCE   282 AA;  33962 MW;  0C6A770634E5F58B CRC64;
     MRTEKEILNL VSEFAYQRSN VKIIALEGSR TNENIKKDKF QDYDFAFFVS DIEYFTHEES
     WLSLFGELLF IQKPEDMELF PPDLDYGYSY IMYFKDGIKM DITLINLKDL NRYFSDSDGL
     VKILVDKDNL VTQEIVPDDS NYWLKKPTER EFYDCCNEFW SVSTYVAKGV FRREILFALD
     HFNNILRPEL LRMISWYIGF NRGFDFSLGK NYKFINKYLT DKEFNMLLAT FEMNGYRKTY
     QSFKLCCELF KYYSNKVSCL GNYNYPNYEK NIENFIRNNY EN