PUR5_LATSS
ID PUR5_LATSS Reviewed; 342 AA.
AC Q93MM7; Q38XW5;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000255|HAMAP-Rule:MF_00741};
DE EC=6.3.3.1 {ECO:0000255|HAMAP-Rule:MF_00741};
DE AltName: Full=AIR synthase {ECO:0000255|HAMAP-Rule:MF_00741};
DE AltName: Full=AIRS {ECO:0000255|HAMAP-Rule:MF_00741};
DE AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000255|HAMAP-Rule:MF_00741};
GN Name=purM {ECO:0000255|HAMAP-Rule:MF_00741}; OrderedLocusNames=LCA_0660;
OS Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS subsp. sakei).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Latilactobacillus.
OX NCBI_TaxID=314315;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11832506; DOI=10.1099/00221287-148-2-421;
RA Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C.,
RA Alpert C.-A., Zagorec M.;
RT "Physical and genetic map of the Lactobacillus sakei 23K chromosome.";
RL Microbiology 148:421-431(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23K;
RX PubMed=16273110; DOI=10.1038/nbt1160;
RA Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA Zagorec M.;
RT "The complete genome sequence of the meat-borne lactic acid bacterium
RT Lactobacillus sakei 23K.";
RL Nat. Biotechnol. 23:1527-1533(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP
CC = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981,
CC ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00741};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00741}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00741}.
CC -!- SIMILARITY: Belongs to the AIR synthase family. {ECO:0000255|HAMAP-
CC Rule:MF_00741}.
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DR EMBL; AF401037; AAK92512.1; -; Genomic_DNA.
DR EMBL; CR936503; CAI54964.1; -; Genomic_DNA.
DR RefSeq; WP_011374369.1; NC_007576.1.
DR AlphaFoldDB; Q93MM7; -.
DR SMR; Q93MM7; -.
DR STRING; 314315.LCA_0660; -.
DR EnsemblBacteria; CAI54964; CAI54964; LCA_0660.
DR KEGG; lsa:LCA_0660; -.
DR eggNOG; COG0150; Bacteria.
DR HOGENOM; CLU_047116_0_0_9; -.
DR OMA; EPLFMTD; -.
DR OrthoDB; 923547at2; -.
DR BioCyc; LSAK314315:LCA_RS03350-MON; -.
DR UniPathway; UPA00074; UER00129.
DR Proteomes; UP000002707; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02196; PurM; 1.
DR Gene3D; 3.30.1330.10; -; 1.
DR Gene3D; 3.90.650.10; -; 1.
DR HAMAP; MF_00741; AIRS; 1.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR016188; PurM-like_N.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR004733; PurM_cligase.
DR PANTHER; PTHR10520; PTHR10520; 1.
DR Pfam; PF00586; AIRS; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR SUPFAM; SSF55326; SSF55326; 1.
DR SUPFAM; SSF56042; SSF56042; 1.
DR TIGRFAMs; TIGR00878; purM; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Ligase; Nucleotide-binding; Purine biosynthesis;
KW Reference proteome.
FT CHAIN 1..342
FT /note="Phosphoribosylformylglycinamidine cyclo-ligase"
FT /id="PRO_0000148218"
SQ SEQUENCE 342 AA; 36399 MW; 7F0C4561E12B266F CRC64;
MTDAYQKAGV DVTAGYEVVA RIQKKVGADN HNIGSFGGQY ALEMAQYQKP VLVSSTDGVG
TKLMVAFAAD QHATIGIDCV AMCVNDIVAQ GAQPLYFLDY LATGKTDPDK IEDIVAGVLE
GCKQANMALI GGETAEMPGM YAAKHYDVAG FAVGIAEQDA LVTGETIQAG DVLIGLASSG
IHSNGYSLVR KIFFEQNNLT VASQLPELPG KTLGDWLLTP TKIYVEDLQP LLQQRVIKGA
AHITGGGFIE NVPRMLPADL AAHLTLGSWP ILPIFKALQQ YGQLAEMEMY NIFNMGIGMV
LAVAPEAAPA VLAQLNAKQE QAYQIGTVQK RQQAAVELVT AK