ID   PUR5_STRFR              Reviewed;         182 AA.
AC   P40178;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Putative phosphoribosylformylglycinamidine cyclo-ligase;
DE            Short=AIRS;
DE            EC=6.3.3.1;
DE   AltName: Full=AIR synthase;
DE   AltName: Full=Phosphoribosyl-aminoimidazole synthetase;
DE   Flags: Fragment;
GN   Name=purM;
OS   Streptomyces fradiae (Streptomyces roseoflavus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1906;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C373.1;
RX   PubMed=7928973; DOI=10.1128/jb.176.19.6107-6119.1994;
RA   Tang L., Zhang Y.X., Hutchinson C.R.;
RT   "Amino acid catabolism and antibiotic synthesis: valine is a source of
RT   precursors for macrolide biosynthesis in Streptomyces ambofaciens and
RT   Streptomyces fradiae.";
RL   J. Bacteriol. 176:6107-6119(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP
CC         = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981,
CC         ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AIR synthase family. {ECO:0000305}.
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DR   EMBL; L33872; AAA62389.1; -; Genomic_DNA.
DR   AlphaFoldDB; P40178; -.
DR   SMR; P40178; -.
DR   STRING; 1906.SFRA_10730; -.
DR   eggNOG; COG0150; Bacteria.
DR   UniPathway; UPA00074; UER00129.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.650.10; -; 1.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   PANTHER; PTHR10520; PTHR10520; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Ligase; Nucleotide-binding; Purine biosynthesis.
FT   CHAIN           <1..182
FT                   /note="Putative phosphoribosylformylglycinamidine cyclo-
FT                   ligase"
FT                   /id="PRO_0000148257"
FT   NON_TER         1
SQ   SEQUENCE   182 AA;  18971 MW;  EACE0DB622167CAB CRC64;
     IRAGDAVIAM ASSGLHSNGY SLVRHVLFDG AGYALDREIP EFGRTLGEEL LEPTRIYSLD
     CLALTRTTEV HAFSHITGGG LANNLARVIP DGLHATVDRA TWTPAPVFGL VGSAGSVERT
     ELEKTLNMGV GMIAVVAPEG ADAALATLAD RGVDAWICGE ITDRGESGEH AEAVALTGDY
     AV