PUR71_BRADU
ID PUR71_BRADU Reviewed; 255 AA.
AC Q89IB0;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase A;
DE EC=6.3.2.6;
DE AltName: Full=SAICAR synthetase A;
GN Name=purC1; OrderedLocusNames=bll5729;
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium.
OX NCBI_TaxID=224911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC 4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
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DR EMBL; BA000040; BAC50994.1; -; Genomic_DNA.
DR RefSeq; NP_772369.1; NC_004463.1.
DR RefSeq; WP_008974302.1; NC_004463.1.
DR AlphaFoldDB; Q89IB0; -.
DR SMR; Q89IB0; -.
DR STRING; 224911.27354005; -.
DR PRIDE; Q89IB0; -.
DR EnsemblBacteria; BAC50994; BAC50994; BAC50994.
DR GeneID; 64025498; -.
DR KEGG; bja:bll5729; -.
DR PATRIC; fig|224911.5.peg.5843; -.
DR eggNOG; COG0152; Bacteria.
DR HOGENOM; CLU_061495_2_0_5; -.
DR InParanoid; Q89IB0; -.
DR OMA; EFCYKND; -.
DR PhylomeDB; Q89IB0; -.
DR UniPathway; UPA00074; UER00131.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IBA:GO_Central.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR CDD; cd01415; SAICAR_synt_PurC; 1.
DR HAMAP; MF_00137; SAICAR_synth; 1.
DR InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR InterPro; IPR033934; SAICAR_synt_PurC.
DR InterPro; IPR001636; SAICAR_synth.
DR InterPro; IPR018236; SAICAR_synthetase_CS.
DR Pfam; PF01259; SAICAR_synt; 1.
DR TIGRFAMs; TIGR00081; purC; 1.
DR PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW Reference proteome.
FT CHAIN 1..255
FT /note="Phosphoribosylaminoimidazole-succinocarboxamide
FT synthase A"
FT /id="PRO_0000100807"
SQ SEQUENCE 255 AA; 29186 MW; 961AB39593EEBF19 CRC64;
MSRRRRIYEG KAKVLYEGPE PGTLIQHFKD DATAFNAKKH QVIEGKGVLN NRISEYLFQH
LNDIGVPTHF IRRLNMREQL IREVEIVPLE VVVRNVAAGS LSQRLGIEEG TQLPRSIIEF
YYKNDQLNDP MVSEEHITAF GWATPQEIDD IMALAIRVND FLTGLFLGIG IRLVDFKMEC
GRLFENEMMR IIVADEISPD SCRLWDIKSN EKLDKDRFRR DLGGLLEAYT EVAKRLGILM
ENERPAGSGP VLVKS
