PUR71_CAUVC
ID PUR71_CAUVC Reviewed; 252 AA.
AC Q9A5F9;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase 1;
DE EC=6.3.2.6;
DE AltName: Full=SAICAR synthetase 1;
GN Name=purC1; Synonyms=purC; OrderedLocusNames=CC_2491;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC 4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
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DR EMBL; AE005673; AAK24462.1; -; Genomic_DNA.
DR PIR; B87558; B87558.
DR RefSeq; NP_421294.1; NC_002696.2.
DR RefSeq; WP_010920349.1; NC_002696.2.
DR AlphaFoldDB; Q9A5F9; -.
DR SMR; Q9A5F9; -.
DR STRING; 190650.CC_2491; -.
DR EnsemblBacteria; AAK24462; AAK24462; CC_2491.
DR KEGG; ccr:CC_2491; -.
DR PATRIC; fig|190650.5.peg.2509; -.
DR eggNOG; COG0152; Bacteria.
DR HOGENOM; CLU_061495_2_0_5; -.
DR OMA; EFCYKND; -.
DR BioCyc; CAULO:CC2491-MON; -.
DR UniPathway; UPA00074; UER00131.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR CDD; cd01415; SAICAR_synt_PurC; 1.
DR HAMAP; MF_00137; SAICAR_synth; 1.
DR InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR InterPro; IPR033934; SAICAR_synt_PurC.
DR InterPro; IPR001636; SAICAR_synth.
DR InterPro; IPR018236; SAICAR_synthetase_CS.
DR Pfam; PF01259; SAICAR_synt; 1.
DR TIGRFAMs; TIGR00081; purC; 1.
DR PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW Reference proteome.
FT CHAIN 1..252
FT /note="Phosphoribosylaminoimidazole-succinocarboxamide
FT synthase 1"
FT /id="PRO_0000100813"
SQ SEQUENCE 252 AA; 28621 MW; B40C0BD74B33EA9B CRC64;
MTTRRKKIYE GKAKILYEGP EPGTLIQYFK DDATAFNAQK KAILEGKGVI NNRISEYIMT
RLNGIGVQNH FIRRLNLREQ LIKEVEIVPL EVVVRNIAAG SIATRLGLTE GQPLPRSIIE
FYYKDDKLGD PMVTEEHITA FNWAATQEID DMMAMALRVN DYLSGLFAGV GITLVDFKVE
FGRVYEGDFS RVILADEISP DSCRLWDTVT NEKLDKDRFR RDLGNVIESY TEVARRLGIM
KEMPTVIQGG VH
