ID   PUR72_AGRFC             Reviewed;         316 AA.
AC   Q8UCE7;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase 2;
GN   Name=purC2; OrderedLocusNames=Atu2548; ORFNames=AGR_C_4615;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
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DR   EMBL; AE007869; AAK88273.1; -; Genomic_DNA.
DR   PIR; AC2889; AC2889.
DR   PIR; H97664; H97664.
DR   RefSeq; NP_355488.1; NC_003062.2.
DR   RefSeq; WP_010972392.1; NC_003062.2.
DR   AlphaFoldDB; Q8UCE7; -.
DR   SMR; Q8UCE7; -.
DR   STRING; 176299.Atu2548; -.
DR   EnsemblBacteria; AAK88273; AAK88273; Atu2548.
DR   KEGG; atu:Atu2548; -.
DR   PATRIC; fig|176299.10.peg.2552; -.
DR   eggNOG; COG0152; Bacteria.
DR   HOGENOM; CLU_045637_0_1_5; -.
DR   OMA; TKFEFGF; -.
DR   PhylomeDB; Q8UCE7; -.
DR   BioCyc; AGRO:ATU2548-MON; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..316
FT                   /note="Putative phosphoribosylaminoimidazole-
FT                   succinocarboxamide synthase 2"
FT                   /id="PRO_0000100795"
SQ   SEQUENCE   316 AA;  35975 MW;  ACF1A66E94889921 CRC64;
     MRILDEAVIP ELPNYYRGKV RENYDLPDGN RIIISTDRLS AFDQILTCIP YKGQVLTQTA
     RYWFEQTKDI CPNHVVSYPD PNVVIGKRLD ILPVEVVVRG YLAGTTGTSI LTLYKKGERQ
     MYGMSLPDGM KDNQILPEPV ITPTSKAFDG GHDEPLTPSE IVEKKLLTQE QWDTLSRYAL
     ALFRHGQEIA AKQGLILVDT KYEFGTDENG TIILADEIHT PDSSRYWMAD SYDESFREGK
     RPASFDKDFV RAWVGERCDP YKDAVPKIPE DLVLQTSQVY IDAYERITGQ RFVPDDSGET
     PLARVRRNLE PFFPGV