ID   PUR72_BRADU             Reviewed;         304 AA.
AC   Q89W81;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Putative phosphoribosylaminoimidazole-succinocarboxamide synthase B;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase 2;
GN   Name=purC2; OrderedLocusNames=bll0812;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000040; BAC46077.1; -; Genomic_DNA.
DR   RefSeq; NP_767452.1; NC_004463.1.
DR   RefSeq; WP_011083634.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89W81; -.
DR   SMR; Q89W81; -.
DR   STRING; 224911.27349061; -.
DR   EnsemblBacteria; BAC46077; BAC46077; BAC46077.
DR   GeneID; 64020674; -.
DR   KEGG; bja:bll0812; -.
DR   PATRIC; fig|224911.44.peg.187; -.
DR   eggNOG; COG0152; Bacteria.
DR   HOGENOM; CLU_045637_0_2_5; -.
DR   InParanoid; Q89W81; -.
DR   OMA; TKFEFGF; -.
DR   PhylomeDB; Q89W81; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IBA:GO_Central.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR001636; SAICAR_synth.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..304
FT                   /note="Putative phosphoribosylaminoimidazole-
FT                   succinocarboxamide synthase B"
FT                   /id="PRO_0000100808"
SQ   SEQUENCE   304 AA;  33701 MW;  EA918E87E17BCB46 CRC64;
     MTTMLSSDLP LPKIGRGKVR DIYAVDDDRL LLLTTDRISA FDVVMGETIP MKGAVLTQIS
     AFWFGELEGV VPHHMISADT DEIIAAVPAL KPHRAEILGR AMLSRRTTVF PIECVIRGYL
     SGSAWKEYAT SGTLAGEKLK AGLVESEKLE PAIFSPATKA ETGHDENITI ARMREVVGDE
     TAYTLESMTR AIYTLGEELA REQGIIIADT KFEFGRDKDG RIILIDEVMT PDSSRFWAVD
     AYKPGQPQAS FDKQPLRDYL DVERRAGRWN GDAPPPPLPA SVVEATSKRY LEAYRRVTGK
     ELKI