ID   PUR72_CAUVC             Reviewed;         320 AA.
AC   Q9A3G2;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase 2;
GN   Name=purC2; OrderedLocusNames=CC_3242;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005673; AAK25204.1; -; Genomic_DNA.
DR   PIR; H87650; H87650.
DR   RefSeq; NP_422036.1; NC_002696.2.
DR   RefSeq; WP_010921075.1; NC_002696.2.
DR   AlphaFoldDB; Q9A3G2; -.
DR   SMR; Q9A3G2; -.
DR   STRING; 190650.CC_3242; -.
DR   EnsemblBacteria; AAK25204; AAK25204; CC_3242.
DR   KEGG; ccr:CC_3242; -.
DR   PATRIC; fig|190650.5.peg.3247; -.
DR   eggNOG; COG0152; Bacteria.
DR   HOGENOM; CLU_045637_0_1_5; -.
DR   OMA; TKFEFGF; -.
DR   BioCyc; CAULO:CC3242-MON; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..320
FT                   /note="Putative phosphoribosylaminoimidazole-
FT                   succinocarboxamide synthase 2"
FT                   /id="PRO_0000100814"
SQ   SEQUENCE   320 AA;  34930 MW;  9DDF4098C98AB4C3 CRC64;
     MTLSAPNALA VVDLPCLPNH YRGKVRDNYD LPDGRRVIVA SDRLSAFDRN LCAVPGKGQV
     LTETARFWFD ATADICPNHV VAYPDPNVLI GKRLKMLPVE LVVRGYLAGT TSTSILTLYN
     KGERQMYGVT LPDGLKANQR LPQAILTPTS KAADGDHDAP LSPDEVLAQG LVTPAQWEQL
     SAYALALFAR GQAMAAERGL ILADTKYEFG LDETGAIVLA DEIHTPDSSR FWKAATYEAR
     FEAGQRPESF DKDFVRAWVA ERCDPYNDSI PEIPAELIAQ ASAVYIEAFE AITGQTFAAP
     DASEPVMARV KRNLDAYLAG