ID   PUR7_ARCFU              Reviewed;         331 AA.
AC   O28996;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Putative phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC; OrderedLocusNames=AF_1272;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family. Highly divergent.
CC       {ECO:0000305}.
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DR   EMBL; AE000782; AAB89972.1; -; Genomic_DNA.
DR   PIR; G69408; G69408.
DR   RefSeq; WP_010878767.1; NC_000917.1.
DR   AlphaFoldDB; O28996; -.
DR   SMR; O28996; -.
DR   STRING; 224325.AF_1272; -.
DR   EnsemblBacteria; AAB89972; AAB89972; AF_1272.
DR   GeneID; 24794883; -.
DR   KEGG; afu:AF_1272; -.
DR   eggNOG; arCOG04421; Archaea.
DR   HOGENOM; CLU_045637_1_0_2; -.
DR   OMA; TKFEFGF; -.
DR   OrthoDB; 47738at2157; -.
DR   PhylomeDB; O28996; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR001636; SAICAR_synth.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..331
FT                   /note="Putative phosphoribosylaminoimidazole-
FT                   succinocarboxamide synthase"
FT                   /id="PRO_0000100906"
SQ   SEQUENCE   331 AA;  37780 MW;  23CC5DFF949E21D8 CRC64;
     MGSVKDLVVL KEPAEKPGLG RFIFSNRYSV FDYGEMPDKI EDKGRALCMV TAYFFEKLEE
     AGIATHYLGL VEGGKVRRFD EVENAVNEME VKLVRVIKPK NGDYSIFKTL KGNFLVPLEI
     IYRNSIPEGS SLLRRIERGE AKPEDFGLTK IEAGMRLERP IVDFSTKLED VDRYLSHSEA
     KEISGLSDEE FEALKELVVK VDEIITREVS KAGLINEDGK IEVALDDERN LMVVDAVGTP
     DECRFSFDGF EVSKELLREY YRKTEWYDKV RQLKGQEGWR EAVGLPPPLP DEVREGVSNL
     YRAFCNEVTG RKFFDAPKLK EVVSQLKEVL E