ID   PUR7_HALSA              Reviewed;         338 AA.
AC   Q9HNU7;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Putative phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC; OrderedLocusNames=VNG_1939G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family. Highly divergent.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG20123.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE004437; AAG20123.1; ALT_INIT; Genomic_DNA.
DR   PIR; G84344; G84344.
DR   RefSeq; WP_012289411.1; NC_002607.1.
DR   AlphaFoldDB; Q9HNU7; -.
DR   SMR; Q9HNU7; -.
DR   STRING; 64091.VNG_1939G; -.
DR   PaxDb; Q9HNU7; -.
DR   EnsemblBacteria; AAG20123; AAG20123; VNG_1939G.
DR   GeneID; 5954349; -.
DR   KEGG; hal:VNG_1939G; -.
DR   PATRIC; fig|64091.14.peg.1482; -.
DR   HOGENOM; CLU_045637_1_0_2; -.
DR   InParanoid; Q9HNU7; -.
DR   OrthoDB; 47738at2157; -.
DR   PhylomeDB; Q9HNU7; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IBA:GO_Central.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   Pfam; PF01259; SAICAR_synt; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..338
FT                   /note="Putative phosphoribosylaminoimidazole-
FT                   succinocarboxamide synthase"
FT                   /id="PRO_0000100907"
SQ   SEQUENCE   338 AA;  37124 MW;  127D4EBC2B39183D CRC64;
     MASVKDRRVE SPATDTDLGR GVFEFSDRYS VFDWGEMPDH VPGKGASLCT MGAYTFEQLA
     AAGVPTHYQG VRTPDGETVR LADAPEAPTQ MVIDLTQVPT LPFEDGSYDY DRYHDAGGSN
     YLVPLEVVFR NAVPVGSSLR TRCAPADVGI DADEWPQGPV ELPETIVEFS TKYEEQDRYL
     SRSMADEIAG DADIAELDAL ARRVNETITD CAADAGFVHD DGKLECVYVD GEVRVADVAG
     TFDENRFRFD GREVSKEAVR QFYKRSDPEW VGAVKDAKRA ADERGVADWK SLCEPSPDPL
     PPEILQAAAD LYAAGANRYT AREWFDAPPL GDALDAFE