AAE17_ARATH
ID AAE17_ARATH Reviewed; 721 AA.
AC F4KBF3; Q0WQ54; Q84P18; Q9FN49;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Probable acyl-activating enzyme 17, peroxisomal;
DE EC=6.2.1.-;
GN Name=AAE17; OrderedLocusNames=At5g23050; ORFNames=MYJ24.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-295.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 64-721, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=12805634; DOI=10.1104/pp.103.020552;
RA Shockey J.M., Fulda M.S., Browse J.;
RT "Arabidopsis contains a large superfamily of acyl-activating enzymes.
RT Phylogenetic and biochemical analysis reveals a new class of acyl-coenzyme
RT a synthetases.";
RL Plant Physiol. 132:1065-1076(2003).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=19043666; DOI=10.1007/s11103-008-9431-4;
RA Wiszniewski A.A., Zhou W., Smith S.M., Bussell J.D.;
RT "Identification of two Arabidopsis genes encoding a peroxisomal
RT oxidoreductase-like protein and an acyl-CoA synthetase-like protein that
RT are required for responses to pro-auxins.";
RL Plant Mol. Biol. 69:503-515(2009).
CC -!- FUNCTION: May act as an acid--thiol ligase that activates carboxylic
CC acids by forming acyl-CoAs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems and developing seeds.
CC {ECO:0000269|PubMed:12805634}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:19043666}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09822.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB006708; BAB09822.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED93113.1; -; Genomic_DNA.
DR EMBL; AK228851; BAF00745.1; -; mRNA.
DR EMBL; AY250844; AAP03027.1; -; mRNA.
DR RefSeq; NP_197696.2; NM_122211.3.
DR AlphaFoldDB; F4KBF3; -.
DR SMR; F4KBF3; -.
DR STRING; 3702.AT5G23050.1; -.
DR PaxDb; F4KBF3; -.
DR PRIDE; F4KBF3; -.
DR ProteomicsDB; 243296; -.
DR EnsemblPlants; AT5G23050.1; AT5G23050.1; AT5G23050.
DR GeneID; 832369; -.
DR Gramene; AT5G23050.1; AT5G23050.1; AT5G23050.
DR KEGG; ath:AT5G23050; -.
DR Araport; AT5G23050; -.
DR TAIR; locus:2178277; AT5G23050.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_8_1; -.
DR InParanoid; F4KBF3; -.
DR OMA; RFDNVWT; -.
DR OrthoDB; 899666at2759; -.
DR PRO; PR:F4KBF3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KBF3; baseline and differential.
DR Genevisible; F4KBF3; AT.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; -; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig.
DR InterPro; IPR042099; ANL_N_sf.
DR Pfam; PF00501; AMP-binding; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 2: Evidence at transcript level;
KW Fatty acid metabolism; Ligase; Lipid metabolism; Peroxisome;
KW Reference proteome.
FT CHAIN 1..721
FT /note="Probable acyl-activating enzyme 17, peroxisomal"
FT /id="PRO_0000415727"
FT MOTIF 719..721
FT /note="Microbody targeting signal"
FT /evidence="ECO:0000255"
FT CONFLICT 77
FT /note="L -> P (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="V -> F (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="S -> F (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="K -> N (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="T -> A (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="G -> D (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="N -> K (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 344
FT /note="A -> V (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 389
FT /note="R -> Q (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 533
FT /note="D -> G (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 554
FT /note="H -> Y (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 660..663
FT /note="FSNP -> LSNH (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
FT CONFLICT 693
FT /note="P -> L (in Ref. 4; AAP03027)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 721 AA; 79181 MW; 6B4436E4C408258B CRC64;
MAYKSLNSIT KSDIEALGIS GDVSEKLLRD LEDIIHGSST PPETWIQISR RILHPNLPFS
FHQMMYYGCY KDFGPDLPAW IPDPKVASLT NVGKLLEKRG KEFLGGNYKN PVSSFSSFQE
FSVSNPEVYW KTVLDELNIL FSVPPKCILE KDTSGDNPGG KWLPGAYLNP ARNCLTNGFK
RRLDDIVIRW RDEGSDDLPV NTMTLLELRS QVWLAAHALS ALGLEEESAI AVDMPMNVES
VIIYLAIVLA GHVVVSIADS FSPREISTRL KISKAKAIFT QDVIIRGDKS IPLYRRVVDA
EAPLAIVVPA RGSSCRMKLR EKDLSWNNFL GNARNLRGVE YVAAEKPAGA YTNILFSSGT
TGEPKAIPWT NISPLKSAAD AWCHLDVQRG DVVAWPTNLG WMMGPWLVYA SLINGACMGL
YNGSPLGPTF AKFVQDAEVS VLGVIPSIVR TWQNSNSTSG YDWSRIRCFG STGEASNIDE
YLWLMGRAHY KPVIEYCGGT EIGGSFISGS LLQPQSLAAF STAAMGCKLF ILDEDSNPIP
PYAAGVGELA LCPHMFGASS TLLNGNHFKV YFQGMPTFQG QILRRHGDLF ERTSKGYYRA
HGRADDTMNL GGIKVGSIEI ERVCNSVDDS VLETAAIGVP PPSGGPEQLV IAVVFKSPEF
SNPDLNLLKK SFNSEIQKKL NPLFKVSSVV TLPSLPRTAT NKVMRRVLRQ QLTQTGLNSK
L
