ID   PUR7_LACLA              Reviewed;         236 AA.
AC   O68830;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC; OrderedLocusNames=LL1533; ORFNames=L177350;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-115.
RC   STRAIN=CHCC285;
RX   PubMed=9683487; DOI=10.1128/jb.180.15.3900-3906.1998;
RA   Kilstrup M., Jessing S.G., Wichmand-Jorgensen S.B., Madsen M., Nilsson D.;
RT   "Activation control of pur gene expression in Lactococcus lactis: proposal
RT   for a consensus activator binding sequence based on deletion analysis and
RT   site-directed mutagenesis of purC and purD promoter regions.";
RL   J. Bacteriol. 180:3900-3906(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005176; AAK05631.1; -; Genomic_DNA.
DR   EMBL; AF054888; AAC32329.1; -; Genomic_DNA.
DR   PIR; E86816; E86816.
DR   RefSeq; NP_267689.1; NC_002662.1.
DR   RefSeq; WP_010906022.1; NC_002662.1.
DR   AlphaFoldDB; O68830; -.
DR   SMR; O68830; -.
DR   STRING; 272623.L177350; -.
DR   PaxDb; O68830; -.
DR   EnsemblBacteria; AAK05631; AAK05631; L177350.
DR   KEGG; lla:L177350; -.
DR   PATRIC; fig|272623.7.peg.1644; -.
DR   eggNOG; COG0152; Bacteria.
DR   HOGENOM; CLU_061495_2_0_9; -.
DR   OMA; EFCYKND; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   CDD; cd01415; SAICAR_synt_PurC; 1.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR033934; SAICAR_synt_PurC.
DR   InterPro; IPR001636; SAICAR_synth.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..236
FT                   /note="Phosphoribosylaminoimidazole-succinocarboxamide
FT                   synthase"
FT                   /id="PRO_0000100833"
SQ   SEQUENCE   236 AA;  27136 MW;  BD8E02C8E27F0076 CRC64;
     MEKEKLLYEG KAKKLYFTDD SEVLWVEYCD QATALNGARK EQITGKGALN NQITSLIFEK
     LNAEGLETHF IEKLSKTEQL NRKVSIIPLE VVLRNVVAGS FAKRFGLEEG IVLQEPIVEF
     YYKDDALDDP FINDEHVRFL NIATYSEIEF LKSETRKINE ILKKIWAEIG LTLVDFKLEF
     GRLADGRIIL ADEISPDTSR LWDANGQHMD KDVFRRNIGD LVETYTEVLN LLENAK