PUR7_PICAN
ID PUR7_PICAN Reviewed; 303 AA.
AC Q96VP6;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE EC=6.3.2.6;
DE AltName: Full=SAICAR synthetase;
GN Name=ADE1; Synonyms=PUR7;
OS Pichia angusta (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=870730;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 14754 / CBS 1976 / JCM 3620 / NBRC 0799 / NCYC 495 / NRRL
RC Y-1798 / VKM Y-1397;
RX PubMed=12702317; DOI=10.1111/j.1567-1364.2002.tb00064.x;
RA Haan G.J., van Dijk R., Kiel J.A.K.W., Veenhuis M.;
RT "Characterization of the Hansenula polymorpha PUR7 gene and its use as
RT selectable marker for targeted chromosomal integration.";
RL FEMS Yeast Res. 2:17-24(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC 4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC -!- SIMILARITY: Belongs to the SAICAR synthetase family. {ECO:0000305}.
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DR EMBL; AY034035; AAK55758.1; -; Genomic_DNA.
DR AlphaFoldDB; Q96VP6; -.
DR SMR; Q96VP6; -.
DR PhylomeDB; Q96VP6; -.
DR UniPathway; UPA00074; UER00131.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00137; SAICAR_synth; 1.
DR InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR InterPro; IPR001636; SAICAR_synth.
DR InterPro; IPR018236; SAICAR_synthetase_CS.
DR Pfam; PF01259; SAICAR_synt; 1.
DR TIGRFAMs; TIGR00081; purC; 1.
DR PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis.
FT CHAIN 1..303
FT /note="Phosphoribosylaminoimidazole-succinocarboxamide
FT synthase"
FT /id="PRO_0000100925"
SQ SEQUENCE 303 AA; 33891 MW; E6F78F48610EA997 CRC64;
MTVTQTNLDG ILPLVARGKV RDIYQVDDNM LLFVATDRIS AYDVIMENGI KDKGKILTQL
SVFWFNLLSD VIPNHLVASS DKDIFAKLPE QLSEPKYKAQ LAGRSLLVKK HKLVPLEAIV
RGYITGSAWK EYKKSSTVHG LPVKSGLQES EAFEKPIFTP STKAEQGQHD ENISPEQAAQ
LVGEELCAEV AQKAIALYSK ARDYALSRGI ILADTKFEFG LNENNELVLV DEVLTPDSSR
FWDAKKYELG RSQESFDKQF LRDWLTSHQL NGKEGVSMTE EIAAKTAAKY KEAYEALTGK
TWA