ATP6_DICDI
ID ATP6_DICDI Reviewed; 244 AA.
AC Q27559; Q9XPJ7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=ATP synthase subunit a;
DE AltName: Full=F-ATPase protein 6;
GN Name=atp6; ORFNames=DDB_G0294014;
OS Dictyostelium discoideum (Slime mold).
OG Mitochondrion.
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=10821186; DOI=10.1007/pl00008685;
RA Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K.,
RA Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene
RT content and genome organization.";
RL Mol. Gen. Genet. 263:514-519(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-244.
RC STRAIN=AX3;
RX PubMed=9560439; DOI=10.1007/s002940050341;
RA Iwamoto M., Pi M., Kurihara M., Morio T., Tanaka Y.;
RT "A ribosomal protein gene cluster is encoded in the mitochondrial DNA of
RT Dictyostelium discoideum: UGA termination codons and similarity of gene
RT order to Acanthamoeba castellanii.";
RL Curr. Genet. 33:304-310(1998).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Key component of the
CC proton channel; it may play a direct role in the translocation of
CC protons across the membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC subunits: a, b and c (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR EMBL; AB000109; BAA78068.1; -; Genomic_DNA.
DR EMBL; D21196; BAA04732.1; -; Genomic_DNA.
DR PIR; T43764; T43764.
DR RefSeq; NP_050086.1; NC_000895.1.
DR AlphaFoldDB; Q27559; -.
DR SMR; Q27559; -.
DR GeneID; 2193914; -.
DR KEGG; ddi:DidioMp19; -.
DR dictyBase; DDB_G0294014; atp6.
DR InParanoid; Q27559; -.
DR OMA; FFDQFMS; -.
DR PhylomeDB; Q27559; -.
DR PRO; PR:Q27559; -.
DR Proteomes; UP000002195; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IBA:GO_Central.
DR Gene3D; 1.20.120.220; -; 1.
DR HAMAP; MF_01393; ATP_synth_a_bact; 1.
DR InterPro; IPR000568; ATP_synth_F0_asu.
DR InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR InterPro; IPR035908; F0_ATP_A_sf.
DR PANTHER; PTHR11410; PTHR11410; 1.
DR Pfam; PF00119; ATP-synt_A; 1.
DR PRINTS; PR00123; ATPASEA.
DR SUPFAM; SSF81336; SSF81336; 1.
DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR PROSITE; PS00449; ATPASE_A; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..244
FT /note="ATP synthase subunit a"
FT /id="PRO_0000312373"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 27802 MW; E3A436C7E88F3A96 CRC64;
MKSLFEQFEI DLYCIIITRF FDISITTITV YLGLLMVIVI GMYKVSLYKA TIIGGNNWQH
IGEMIYEFVV DLIIEQVGKP GILFFPFIMS LFLFVLTLNV MGLIPLSFTV TGQLLVTFTL
AITIMIGITI WGFRIHGIKF LNIFVPSGIE PWLLPLLVFI EIMSYVLRPI SLAVRLFANM
LAGHLLIHII GVAAIYLMQF YFIGILPWIC VIAFMFLELG IAFLQAYVFV LLTLIYIANI
INLH
