PUR7_THEAC
ID PUR7_THEAC Reviewed; 294 AA.
AC Q9HLC0;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 26-JUL-2002, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000255|HAMAP-Rule:MF_00137};
DE EC=6.3.2.6 {ECO:0000255|HAMAP-Rule:MF_00137};
DE AltName: Full=SAICAR synthetase {ECO:0000255|HAMAP-Rule:MF_00137};
GN Name=purC {ECO:0000255|HAMAP-Rule:MF_00137}; OrderedLocusNames=Ta0309;
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC 4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00137};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC {ECO:0000255|HAMAP-Rule:MF_00137}.
CC -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC {ECO:0000255|HAMAP-Rule:MF_00137}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC11454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL445063; CAC11454.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_048161525.1; NC_002578.1.
DR AlphaFoldDB; Q9HLC0; -.
DR SMR; Q9HLC0; -.
DR STRING; 273075.Ta0309; -.
DR PRIDE; Q9HLC0; -.
DR EnsemblBacteria; CAC11454; CAC11454; CAC11454.
DR GeneID; 1455932; -.
DR KEGG; tac:Ta0309; -.
DR eggNOG; arCOG04421; Archaea.
DR HOGENOM; CLU_045637_0_1_2; -.
DR OMA; TKFEFGF; -.
DR OrthoDB; 47738at2157; -.
DR UniPathway; UPA00074; UER00131.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00137; SAICAR_synth; 1.
DR InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR InterPro; IPR001636; SAICAR_synth.
DR InterPro; IPR018236; SAICAR_synthetase_CS.
DR Pfam; PF01259; SAICAR_synt; 1.
DR TIGRFAMs; TIGR00081; purC; 1.
DR PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW Reference proteome.
FT CHAIN 1..294
FT /note="Phosphoribosylaminoimidazole-succinocarboxamide
FT synthase"
FT /id="PRO_0000100921"
SQ SEQUENCE 294 AA; 34186 MW; F62B5823AA910E65 CRC64;
MKIIAKGKVK DVYDDGDTLV FRFSNRISVF DKIIPTEIEN KGESLCRTSS FWFRYIGERG
IKNHFIEMID NRTMRVRKYD VPEKVSPGSS GYVIPLEFIT RHYVAGSLYD RLKAGSTKPA
DIGLNHFPDY GEKLPSPVFE VTTKREKTDR LLDIDEALEI SGLTREEYAE IRETILKIDE
MMEQEVGKRG LIHADGKKEV ALGKEREPII VDTFGTADED RFWEKKEYDA GRIVELSKEM
VRQYYRSTGY HDRLYEARSR GMPEPDIPPL PEDMARKVSD LYKTMYERIT GQKW
