ATP6_DROSI
ID ATP6_DROSI Reviewed; 224 AA.
AC P50269; Q9MD63; Q9MGK7; Q9MGL1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=ATP synthase subunit a;
DE AltName: Full=F-ATPase protein 6;
GN Name=mt:ATPase6; Synonyms=ATP6, ATPase6;
OS Drosophila simulans (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8365657; DOI=10.1017/s0016672300031360;
RA Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.;
RT "Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high
RT level of polymorphism in D. melanogaster.";
RL Genet. Res. 61:195-204(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AU023, KY007, KY045, KY201, and KY215;
RX PubMed=14660690; DOI=10.1093/molbev/msh028;
RA Ballard J.W.O.;
RT "Sequential evolution of a symbiont inferred from the host: Wolbachia and
RT Drosophila simulans.";
RL Mol. Biol. Evol. 21:428-442(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD199, MD221,
RC MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, Sc00, TT00, and
RC TT01;
RX PubMed=10903373; DOI=10.1007/s002390010067;
RA Ballard J.W.;
RT "Comparative genomics of mitochondrial DNA in Drosophila simulans.";
RL J. Mol. Evol. 51:64-75(2000).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Key component of the
CC proton channel; it may play a direct role in the translocation of
CC protons across the membrane.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC subunits: a, b and c.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR EMBL; AY518670; AAR91396.1; -; Genomic_DNA.
DR EMBL; AY518671; AAR91405.1; -; Genomic_DNA.
DR EMBL; AY518672; AAR91418.1; -; Genomic_DNA.
DR EMBL; AY518673; AAR91431.1; -; Genomic_DNA.
DR EMBL; AY518674; AAR91444.1; -; Genomic_DNA.
DR EMBL; AF200833; AAF77293.1; -; Genomic_DNA.
DR EMBL; AF200834; AAF77307.1; -; Genomic_DNA.
DR EMBL; AF200835; AAF77320.1; -; Genomic_DNA.
DR EMBL; AF200836; AAF77333.1; -; Genomic_DNA.
DR EMBL; AF200837; AAF77346.1; -; Genomic_DNA.
DR EMBL; AF200838; AAF77359.1; -; Genomic_DNA.
DR EMBL; AF200839; AAF77373.1; -; Genomic_DNA.
DR EMBL; AF200840; AAF77385.1; -; Genomic_DNA.
DR EMBL; AF200841; AAF77398.1; -; Genomic_DNA.
DR EMBL; AF200842; AAF77410.1; -; Genomic_DNA.
DR EMBL; AF200843; AAF77424.1; -; Genomic_DNA.
DR EMBL; AF200844; AAF77437.1; -; Genomic_DNA.
DR EMBL; AF200845; AAF77450.1; -; Genomic_DNA.
DR EMBL; AF200846; AAF77463.1; -; Genomic_DNA.
DR EMBL; AF200847; AAF77476.1; -; Genomic_DNA.
DR EMBL; AF200848; AAF77489.1; -; Genomic_DNA.
DR EMBL; AF200849; AAF77503.1; -; Genomic_DNA.
DR EMBL; AF200850; AAF77515.1; -; Genomic_DNA.
DR EMBL; AF200851; AAF77529.1; -; Genomic_DNA.
DR EMBL; AF200852; AAF77541.1; -; Genomic_DNA.
DR EMBL; AF200853; AAF77554.1; -; Genomic_DNA.
DR EMBL; AF200854; AAF77567.1; -; Genomic_DNA.
DR RefSeq; NP_982326.1; NC_005781.1.
DR AlphaFoldDB; P50269; -.
DR SMR; P50269; -.
DR STRING; 7240.P50269; -.
DR GeneID; 2760957; -.
DR KEGG; dsi:ATP6; -.
DR CTD; 4508; -.
DR Proteomes; UP000000304; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR Gene3D; 1.20.120.220; -; 1.
DR InterPro; IPR000568; ATP_synth_F0_asu.
DR InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR InterPro; IPR035908; F0_ATP_A_sf.
DR PANTHER; PTHR11410; PTHR11410; 1.
DR Pfam; PF00119; ATP-synt_A; 1.
DR PRINTS; PR00123; ATPASEA.
DR SUPFAM; SSF81336; SSF81336; 1.
DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR PROSITE; PS00449; ATPASE_A; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..224
FT /note="ATP synthase subunit a"
FT /id="PRO_0000082117"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 28
FT /note="L -> I (in strain: HW00, HW09, NC37, NC48, TT00 and
FT TT01)"
FT VARIANT 115
FT /note="L -> M (in strain: HW00, HW09, NC37, NC48, TT00 and
FT TT01)"
FT VARIANT 119
FT /note="I -> F (in strain: C167)"
FT VARIANT 137
FT /note="I -> V (in strain: HW00, HW09, NC37, NC48, TT00 and
FT TT01)"
FT VARIANT 187
FT /note="V -> I (in strain: HW09)"
SQ SEQUENCE 224 AA; 25065 MW; 9480FE8215156782 CRC64;
MMTNLFSVFD PSAIFNLSLN WLSTFLGLLM IPSIYWLMPS RYNIVWNSIL LTLHKEFKTL
LGPSGHNGST FIFISLFSLI LFNNFMGLFP YIFTSTSHLT LTLSLALPLW LCFMLYGWIN
HTQHMFAHLV PQGTPAILMP FMVCIETISN IIRPGTLAVR LTANMIAGHL LLTLLGNTGP
SMSYLLVTFL LTAQIALLVL ESAVAMIQSY VFAVLSTLYS SEVN
