ATP6_DROYA
ID ATP6_DROYA Reviewed; 224 AA.
AC P00851;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=ATP synthase subunit a;
DE AltName: Full=F-ATPase protein 6;
GN Name=mt:ATPase6; Synonyms=ATP6, ATPase6;
OS Drosophila yakuba (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6306579; DOI=10.1093/nar/11.12.4211;
RA Clary D.O., Wolstenholme D.R.;
RT "Nucleotide sequence of a segment of Drosophila mitochondrial DNA that
RT contains the genes for cytochrome c oxidase subunits II and III and ATPase
RT subunit 6.";
RL Nucleic Acids Res. 11:4211-4227(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2317.6 Ivory Coast;
RX PubMed=3001325; DOI=10.1007/bf02099755;
RA Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence,
RT gene organization, and genetic code.";
RL J. Mol. Evol. 22:252-271(1985).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Key component of the
CC proton channel; it may play a direct role in the translocation of
CC protons across the membrane.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC subunits: a, b and c.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR EMBL; X00924; CAA25442.1; -; Genomic_DNA.
DR EMBL; X03240; CAA26989.1; -; Genomic_DNA.
DR PIR; C93477; PWFF6Y.
DR RefSeq; NP_006906.1; NC_001322.1.
DR AlphaFoldDB; P00851; -.
DR SMR; P00851; -.
DR GeneID; 807632; -.
DR KEGG; dya:ATP6; -.
DR CTD; 4508; -.
DR FlyBase; FBgn0013177; Dyak\mt:ATPase6.
DR Proteomes; UP000002282; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR Gene3D; 1.20.120.220; -; 1.
DR InterPro; IPR000568; ATP_synth_F0_asu.
DR InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR InterPro; IPR035908; F0_ATP_A_sf.
DR PANTHER; PTHR11410; PTHR11410; 1.
DR Pfam; PF00119; ATP-synt_A; 1.
DR PRINTS; PR00123; ATPASEA.
DR SUPFAM; SSF81336; SSF81336; 1.
DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR PROSITE; PS00449; ATPASE_A; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..224
FT /note="ATP synthase subunit a"
FT /id="PRO_0000082118"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 224 AA; 25141 MW; 27D6DBF5791FDD24 CRC64;
MMTNLFSVFD PSAIFNLSLN WLSTFLGLLM IPSIYWLMPS RYNIFWNSIL LTLHKEFKTL
LGPSGHNGST FIFISLFSLI LFNNFMGLFP YIFTSTSHLT LTLSLALPLW LCFMLYGWIN
HTQHMFAHLV PQGTPAILMP FMVCIETISN IIRPGTLAVR LTANMIAGHL LLTLLGNTGP
SMSYLLVTFL LVAQIALLVL ESAVTMIQSY VFAVLSTLYS SEVN
