ID   AAEA_CROS8              Reviewed;         310 AA.
AC   A7MJB1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000255|HAMAP-Rule:MF_01544};
DE            Short=pHBA efflux pump protein A {ECO:0000255|HAMAP-Rule:MF_01544};
GN   Name=aaeA {ECO:0000255|HAMAP-Rule:MF_01544}; OrderedLocusNames=ESA_03629;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000255|HAMAP-
CC       Rule:MF_01544}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01544}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01544}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01544}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABU78839.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000783; ABU78839.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014729772.1; NC_009778.1.
DR   AlphaFoldDB; A7MJB1; -.
DR   SMR; A7MJB1; -.
DR   EnsemblBacteria; ABU78839; ABU78839; ESA_03629.
DR   KEGG; esa:ESA_03629; -.
DR   PATRIC; fig|290339.8.peg.3233; -.
DR   HOGENOM; CLU_018816_15_2_6; -.
DR   OrthoDB; 757027at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01544; AaeA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..310
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeA"
FT                   /id="PRO_0000318563"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01544"
SQ   SEQUENCE   310 AA;  34508 MW;  A0D868053BD47570 CRC64;
     MKLLTTKITR TAITVVLVVL AFIAIFRAWS FYTESPWTRD ARFSADVVAI APDVAGLITS
     VDVHDNQLVK KDQVLFTIDQ PRYQKALEEA EADVAYYQAL ANEKRREAGR RNQLGVQAMS
     REEIDQANNV LQTVLHQLAK AEATRDLAKL DLQRTVIRAP ADGWVTNLNV YTGEFITRGS
     TAVALVKQNS FYVQAYMEET KLEGVRPGFR VEITPLGSNN VLHGTVDSVS AGVTNASSTR
     DAKGMATVDS NLEWVRLAQR VPVRIRLDKQ PGNLYPAGTT ATVVVTGERD RDRSQESAFN
     KLMHRLREFG