ATP6_LOXAF
ID ATP6_LOXAF Reviewed; 222 AA.
AC Q9TA24; Q2I3F6;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=ATP synthase subunit a;
DE AltName: Full=F-ATPase protein 6;
GN Name=MT-ATP6; Synonyms=ATP6, ATPASE6, MTATP6;
OS Loxodonta africana (African elephant).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RA Hauf J., Waddell P.J., Chalwatzis N., Joger U., Zimmermann F.K.;
RT "The complete mitochondrial genome sequence of the African elephant
RT (Loxodonta africana), phylogenetic relationships of Proboscidea to other
RT mammals and D-loop heteroplasmy.";
RL Zoology 102:184-195(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=16448217; DOI=10.1371/journal.pbio.0040073;
RA Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V.,
RA Chumakov I., Grigorenko A.P.;
RT "Complete mitochondrial genome and phylogeny of Pleistocene mammoth
RT Mammuthus primigenius.";
RL PLoS Biol. 4:403-410(2006).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Key component of the
CC proton channel; it may play a direct role in the translocation of
CC protons across the membrane.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC subunits: a, b and c. Component of an ATP synthase complex composed of
CC ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-
CC ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and
CC ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct
CC (By similarity). {ECO:0000250|UniProtKB:P00846,
CC ECO:0000250|UniProtKB:P00847}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA12143.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ224821; CAA12143.1; ALT_INIT; Genomic_DNA.
DR EMBL; DQ316069; ABC17909.1; -; Genomic_DNA.
DR PIR; T45555; T45555.
DR RefSeq; NP_009284.2; NC_000934.1.
DR AlphaFoldDB; Q9TA24; -.
DR SMR; Q9TA24; -.
DR STRING; 9785.ENSLAFP00000029496; -.
DR GeneID; 808788; -.
DR KEGG; lav:808788; -.
DR CTD; 4508; -.
DR eggNOG; KOG4665; Eukaryota.
DR InParanoid; Q9TA24; -.
DR OrthoDB; 1095315at2759; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR Gene3D; 1.20.120.220; -; 1.
DR InterPro; IPR000568; ATP_synth_F0_asu.
DR InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR InterPro; IPR035908; F0_ATP_A_sf.
DR PANTHER; PTHR11410; PTHR11410; 1.
DR Pfam; PF00119; ATP-synt_A; 1.
DR PRINTS; PR00123; ATPASEA.
DR SUPFAM; SSF81336; SSF81336; 1.
DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR PROSITE; PS00449; ATPASE_A; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..222
FT /note="ATP synthase subunit a"
FT /id="PRO_0000082133"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 111
FT /note="P -> L (in Ref. 2; ABC17909)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="S -> L (in Ref. 2; ABC17909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 222 AA; 24576 MW; 5D93F1EEDCF7D6EC CRC64;
MNEELSTFFY VPVGTMMLAI AFPAILLPTP NRLITNRWIT IQQWLIQLIM KQLLSIHNTK
GLSWSLMLIT LTLFIGLTNL LGLLPYSFAP TTQLTVNLSM AIPLWTGTVV PGFRYKTKIS
LAHLLPQGTP MFLIPMIIII ETISLLIRPV TLAVRLTANI TAGHSLIHLT GTATLTLSSI
HSMTITVTFV TVILLTILEL AVALIQAYVF ALLISLYLHE NA
