ID   PURBA_XENLA             Reviewed;         323 AA.
AC   Q6PAC9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Transcriptional activator protein Pur-beta-A;
DE   AltName: Full=Purine-rich element-binding protein B-A;
GN   Name=purb-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind repeated elements in single-stranded DNA and may
CC       participate in transcriptional and translational gene regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC060366; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_018108931.1; XM_018253442.1.
DR   AlphaFoldDB; Q6PAC9; -.
DR   SMR; Q6PAC9; -.
DR   GeneID; 108711569; -.
DR   KEGG; xla:108711569; -.
DR   CTD; 108711569; -.
DR   Xenbase; XB-GENE-6255438; purb.L.
DR   OMA; RFIRVEN; -.
DR   OrthoDB; 1248813at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 108711569; Expressed in brain and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032422; F:purine-rich negative regulatory element binding; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR006628; PUR-bd_fam.
DR   InterPro; IPR030499; PURbeta.
DR   PANTHER; PTHR12611; PTHR12611; 1.
DR   PANTHER; PTHR12611:SF4; PTHR12611:SF4; 1.
DR   Pfam; PF04845; PurA; 1.
DR   SMART; SM00712; PUR; 3.
PE   2: Evidence at transcript level;
KW   Acetylation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..323
FT                   /note="Transcriptional activator protein Pur-beta-A"
FT                   /id="PRO_0000225619"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..309
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   323 AA;  34666 MW;  4AF8A7FB906D9973 CRC64;
     MADGDSGSER GGSSGGPGGF SQHMSREQET QELATKRLDI QNKRFYLDVK QNAKGRFIKI
     AEVGAGGSKS RLTLSMGVAA EFRDYLGDFI EHYAQLGPSS PEQIAQASGE DGAGGPGGPR
     RALKSEFLVR ENRKYYLDLK ENQRGRFLRI RQTINRGPGF SGGAGGGAGL QSGQTIALPA
     QGLIEFRDAL AKLIDDYGGE DDEGVGLGGA GGGGGGGMYG ELPEGTSITV DSKRFFFDVG
     SNKYGVFLRV SEVKPSYRNS ITVPLKAWGK FGGAFCRYSE EMKEIQERQR DKMYERRGPG
     DRERSLGPGG GGDDSETEDV DDD