ID   PURBB_XENLA             Reviewed;         328 AA.
AC   Q8AVS4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Transcriptional activator protein Pur-beta-B;
DE   AltName: Full=Purine-rich element-binding protein B-B;
GN   Name=purb-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind repeated elements in single-stranded DNA and may
CC       participate in transcriptional and translational gene regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC041305; AAH41305.1; -; mRNA.
DR   RefSeq; NP_001079178.1; NM_001085709.1.
DR   AlphaFoldDB; Q8AVS4; -.
DR   SMR; Q8AVS4; -.
DR   BioGRID; 96996; 1.
DR   MaxQB; Q8AVS4; -.
DR   DNASU; 373775; -.
DR   GeneID; 373775; -.
DR   KEGG; xla:373775; -.
DR   CTD; 373775; -.
DR   Xenbase; XB-GENE-949708; purb.S.
DR   OMA; STDEHAY; -.
DR   OrthoDB; 1248813at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 373775; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032422; F:purine-rich negative regulatory element binding; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR006628; PUR-bd_fam.
DR   InterPro; IPR030499; PURbeta.
DR   PANTHER; PTHR12611; PTHR12611; 1.
DR   PANTHER; PTHR12611:SF4; PTHR12611:SF4; 1.
DR   Pfam; PF04845; PurA; 1.
DR   SMART; SM00712; PUR; 3.
PE   2: Evidence at transcript level;
KW   Acetylation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..328
FT                   /note="Transcriptional activator protein Pur-beta-B"
FT                   /id="PRO_0000225620"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   328 AA;  34987 MW;  0DA52225BB7462B9 CRC64;
     MADGDSGSER GGSSGGPSGF SQHMSREQET QELASKRLDI QNKRFYLDVK QNAKGRFIKI
     AEVGAGGSKS RLTLSMAVAA EFRDYLGDFI EHYAQLGPSS PEQIAQASGE DGAGGPGGPR
     RALKSEFLVR ENRKYYLDLK ENQRGRFLRI RQTINRGPGF SGGTGGGPGL QSGQTIALPA
     QGLIEFRDAL AKLIDDYGGE DDEGMGLGSG ASGGGAGGGG MYGELPEGTS ITVDSKRFFF
     DVGSNKYGVF LRVSEVKPSY RNSITVPLKA WGKFGGAFCR YSEEMKEIQE RQRDKMYDRR
     GPGERGGSLG PGAGGGGDDS ETEDVDDD