ID   PURB_DANRE              Reviewed;         297 AA.
AC   Q6PHK6; Q6NW99;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transcriptional activator protein Pur-beta;
DE   AltName: Full=Purine-rich element-binding protein B;
GN   Name=purb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind repeated elements in single-stranded DNA and may
CC       participate in transcriptional and translational gene regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC056517; AAH56517.1; -; mRNA.
DR   EMBL; BC067670; AAH67670.1; -; mRNA.
DR   RefSeq; NP_956841.1; NM_200547.1.
DR   AlphaFoldDB; Q6PHK6; -.
DR   SMR; Q6PHK6; -.
DR   STRING; 7955.ENSDARP00000100627; -.
DR   PaxDb; Q6PHK6; -.
DR   PRIDE; Q6PHK6; -.
DR   Ensembl; ENSDART00000166528; ENSDARP00000136139; ENSDARG00000103546.
DR   GeneID; 393519; -.
DR   KEGG; dre:393519; -.
DR   CTD; 393519; -.
DR   ZFIN; ZDB-GENE-040426-1478; purbb.
DR   eggNOG; KOG3074; Eukaryota.
DR   GeneTree; ENSGT00950000183162; -.
DR   HOGENOM; CLU_057873_1_1_1; -.
DR   InParanoid; Q6PHK6; -.
DR   OMA; HYQRESE; -.
DR   OrthoDB; 1248813at2759; -.
DR   PhylomeDB; Q6PHK6; -.
DR   TreeFam; TF313701; -.
DR   PRO; PR:Q6PHK6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000103546; Expressed in retina and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0032422; F:purine-rich negative regulatory element binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006628; PUR-bd_fam.
DR   PANTHER; PTHR12611; PTHR12611; 1.
DR   Pfam; PF04845; PurA; 1.
DR   SMART; SM00712; PUR; 3.
PE   2: Evidence at transcript level;
KW   Acetylation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..297
FT                   /note="Transcriptional activator protein Pur-beta"
FT                   /id="PRO_0000225618"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   297 AA;  32606 MW;  7ED3143DCBEFE963 CRC64;
     MADGDSGSER GGSSGGLQHF QREQETQELA SKRLDIQNKR FYLDVKQNAK GRFIKIAEVG
     AGGSKSRLTL SMSVAAEFRD YLGDFIEHYA QLGPSSPEQI AQSSGGDDGG PRRALKSEFL
     VRENRKYYLD LKENQRGRFL RIRQTVNRGP GFGVGGGGGP GGGVQAGQTI ALPAQGLIEF
     RDALAKLIDD YGGEDEELSG GPGAAGGYGE LPEGTSIMVD SKRFFFDVGS NKYGVFLRVS
     EVKPSYRNSI TIPFKAWGKF GGAFSRYAEE MKEIQERHRD KMYERREESE GEDVDDD