PURG_HUMAN
ID PURG_HUMAN Reviewed; 347 AA.
AC Q9UJV8; Q8TE64;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Purine-rich element-binding protein gamma;
DE Short=Purine-rich element-binding protein G;
GN Name=PURG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=12034829; DOI=10.1093/nar/30.11.2417;
RA Liu H., Johnson E.M.;
RT "Distinct proteins encoded by alternative transcripts of the PURG gene,
RT located contrapodal to WRN on chromosome 8, determined by differential
RT termination/polyadenylation.";
RL Nucleic Acids Res. 30:2417-2426(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANT [LARGE SCALE ANALYSIS] THR-316.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=PURG-A;
CC IsoId=Q9UJV8-1; Sequence=Displayed;
CC Name=2; Synonyms=PURG-B;
CC IsoId=Q9UJV8-2; Sequence=VSP_021319;
CC -!- TISSUE SPECIFICITY: Isoform 1 is expressed in testis and glioblastoma.
CC Isoform 2 is expressed in fetal lung. {ECO:0000269|PubMed:12034829}.
CC -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC {ECO:0000305}.
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DR EMBL; AF195513; AAF03900.1; -; mRNA.
DR EMBL; AY077841; AAL77218.1; -; mRNA.
DR EMBL; BC106708; AAI06709.1; -; mRNA.
DR CCDS; CCDS34878.1; -. [Q9UJV8-2]
DR CCDS; CCDS6081.1; -. [Q9UJV8-1]
DR RefSeq; NP_001015508.1; NM_001015508.2. [Q9UJV8-2]
DR RefSeq; NP_001310240.1; NM_001323311.1. [Q9UJV8-1]
DR RefSeq; NP_001310241.1; NM_001323312.1. [Q9UJV8-2]
DR RefSeq; NP_037489.1; NM_013357.2. [Q9UJV8-1]
DR AlphaFoldDB; Q9UJV8; -.
DR SMR; Q9UJV8; -.
DR BioGRID; 118979; 226.
DR IntAct; Q9UJV8; 2.
DR MINT; Q9UJV8; -.
DR STRING; 9606.ENSP00000418721; -.
DR iPTMnet; Q9UJV8; -.
DR PhosphoSitePlus; Q9UJV8; -.
DR BioMuta; PURG; -.
DR DMDM; 74720969; -.
DR jPOST; Q9UJV8; -.
DR MassIVE; Q9UJV8; -.
DR MaxQB; Q9UJV8; -.
DR PaxDb; Q9UJV8; -.
DR PeptideAtlas; Q9UJV8; -.
DR PRIDE; Q9UJV8; -.
DR ProteomicsDB; 84664; -. [Q9UJV8-1]
DR ProteomicsDB; 84665; -. [Q9UJV8-2]
DR Antibodypedia; 23258; 94 antibodies from 16 providers.
DR DNASU; 29942; -.
DR Ensembl; ENST00000339382.3; ENSP00000345168.2; ENSG00000172733.12. [Q9UJV8-2]
DR Ensembl; ENST00000475541.2; ENSP00000418721.1; ENSG00000172733.12. [Q9UJV8-1]
DR Ensembl; ENST00000523392.2; ENSP00000466881.2; ENSG00000172733.12. [Q9UJV8-1]
DR GeneID; 29942; -.
DR KEGG; hsa:29942; -.
DR MANE-Select; ENST00000523392.2; ENSP00000466881.2; NM_001323311.2; NP_001310240.1.
DR UCSC; uc003xim.2; human. [Q9UJV8-1]
DR CTD; 29942; -.
DR DisGeNET; 29942; -.
DR GeneCards; PURG; -.
DR HGNC; HGNC:17930; PURG.
DR HPA; ENSG00000172733; Tissue enriched (brain).
DR MIM; 618041; gene.
DR neXtProt; NX_Q9UJV8; -.
DR OpenTargets; ENSG00000172733; -.
DR PharmGKB; PA134879671; -.
DR VEuPathDB; HostDB:ENSG00000172733; -.
DR eggNOG; KOG3074; Eukaryota.
DR GeneTree; ENSGT00950000183162; -.
DR HOGENOM; CLU_057873_1_1_1; -.
DR InParanoid; Q9UJV8; -.
DR OMA; MADGCCR; -.
DR OrthoDB; 1248813at2759; -.
DR PhylomeDB; Q9UJV8; -.
DR TreeFam; TF313701; -.
DR PathwayCommons; Q9UJV8; -.
DR SignaLink; Q9UJV8; -.
DR BioGRID-ORCS; 29942; 5 hits in 1078 CRISPR screens.
DR ChiTaRS; PURG; human.
DR GenomeRNAi; 29942; -.
DR Pharos; Q9UJV8; Tbio.
DR PRO; PR:Q9UJV8; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9UJV8; protein.
DR Bgee; ENSG00000172733; Expressed in sperm and 125 other tissues.
DR ExpressionAtlas; Q9UJV8; baseline and differential.
DR Genevisible; Q9UJV8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0032422; F:purine-rich negative regulatory element binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR006628; PUR-bd_fam.
DR InterPro; IPR030501; PURgamma.
DR PANTHER; PTHR12611; PTHR12611; 1.
DR PANTHER; PTHR12611:SF3; PTHR12611:SF3; 1.
DR Pfam; PF04845; PurA; 1.
DR SMART; SM00712; PUR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..347
FT /note="Purine-rich element-binding protein gamma"
FT /id="PRO_0000255952"
FT DNA_BIND 51..293
FT /evidence="ECO:0000250"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R4E6"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R4E6"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R4E6"
FT VAR_SEQ 289..347
FT /note="VSEVRPPYRNTITVPFKAWTRFGENFIKYEEEMRKICNSHKEKRMDGRKASG
FT EEQECLD -> LTNYPKSRENINLFHCCQIKHKEQPHDTTKTVEE (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:12034829"
FT /id="VSP_021319"
FT VARIANT 26
FT /note="S -> G (in dbSNP:rs11574153)"
FT /id="VAR_053613"
FT VARIANT 143
FT /note="E -> K (in dbSNP:rs7464560)"
FT /id="VAR_053614"
FT VARIANT 241
FT /note="E -> A (in dbSNP:rs11574151)"
FT /id="VAR_053615"
FT VARIANT 316
FT /note="K -> T (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036317"
SQ SEQUENCE 347 AA; 39556 MW; 6134333196DAAFC3 CRC64;
MERARRRGGG GGRGRGGKNV GGSGLSKSRL YPQAQHSHYP HYAASATPNQ AGGAAEIQEL
ASKRVDIQKK RFYLDVKQSS RGRFLKIAEV WIGRGRQDNI RKSKLTLSLS VAAELKDCLG
DFIEHYAHLG LKGHRQEHGH SKEQGSRRRQ KHSAPSPPVS VGSEEHPHSV LKTDYIERDN
RKYYLDLKEN QRGRFLRIRQ TMMRGTGMIG YFGHSLGQEQ TIVLPAQGMI EFRDALVQLI
EDYGEGDIEE RRGGDDDPLE LPEGTSFRVD NKRFYFDVGS NKYGIFLKVS EVRPPYRNTI
TVPFKAWTRF GENFIKYEEE MRKICNSHKE KRMDGRKASG EEQECLD
