ID   ATP6_PARLI              Reviewed;         232 AA.
AC   P12696;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=ATP synthase subunit a;
DE   AltName: Full=F-ATPase protein 6;
GN   Name=ATP6;
OS   Paracentrotus lividus (Common sea urchin).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX   NCBI_TaxID=7656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2544576; DOI=10.1016/s0021-9258(18)60413-2;
RA   Cantatore P., Roberti M., Rainaldi G., Gadaleta M.N., Saccone C.;
RT   "The complete nucleotide sequence, gene organization, and genetic code of
RT   the mitochondrial genome of Paracentrotus lividus.";
RL   J. Biol. Chem. 264:10965-10975(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-232.
RX   PubMed=3596250; DOI=10.1016/0378-1119(87)90091-6;
RA   Cantatore P., Roberti M., Morisco P., Rainaldi G., Gadaleta M.N.,
RA   Saccone C.;
RT   "A novel gene order in the Paracentrotus lividus mitochondrial genome.";
RL   Gene 53:41-54(1987).
CC   -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC       Complex V) produces ATP from ADP in the presence of a proton gradient
CC       across the membrane which is generated by electron transport complexes
CC       of the respiratory chain. F-type ATPases consist of two structural
CC       domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC       - containing the membrane proton channel, linked together by a central
CC       stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC       catalytic domain of F(1) is coupled via a rotary mechanism of the
CC       central stalk subunits to proton translocation. Key component of the
CC       proton channel; it may play a direct role in the translocation of
CC       protons across the membrane.
CC   -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC       - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC       alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC       subunits: a, b and c.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR   EMBL; J04815; AAA68139.1; -; Genomic_DNA.
DR   EMBL; M16522; AAA31993.2; -; Genomic_DNA.
DR   PIR; G34284; G34284.
DR   RefSeq; NP_008127.1; NC_001572.1.
DR   AlphaFoldDB; P12696; -.
DR   SMR; P12696; -.
DR   GeneID; 807714; -.
DR   CTD; 4508; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR   Gene3D; 1.20.120.220; -; 1.
DR   InterPro; IPR000568; ATP_synth_F0_asu.
DR   InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR   InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR   InterPro; IPR035908; F0_ATP_A_sf.
DR   PANTHER; PTHR11410; PTHR11410; 1.
DR   Pfam; PF00119; ATP-synt_A; 1.
DR   PRINTS; PR00123; ATPASEA.
DR   SUPFAM; SSF81336; SSF81336; 1.
DR   TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR   PROSITE; PS00449; ATPASE_A; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..232
FT                   /note="ATP synthase subunit a"
FT                   /id="PRO_0000082150"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   232 AA;  25827 MW;  DB0979ACAA45F87E CRC64;
     MTMTITVSIF GQFFPETLLF IPMNLFSIVF ALSWIAFIYP TNWAPSRFQS IWASFRANVL
     EMIFQNTSPN TAPWAGLITT VFIVILSANV LGLFPYAFTA TSHISLTYSL GFPIWMAVNI
     LGFYLAFNSR LSHLVPQGTP SALIPLMVWI ETLSLFAQPI ALGLRLAANL TAGHLLIFLL
     STAIWLLSSS LMVSSIPIFV IFVLLFILEI GVACIEAYVF TALVHFYLQQ NV